Geniculate Artery Embolization for Treatment of Osteoarthritis

Inclusion Criteria

• 30-80 years of age of any gender;
• Kellgren-Lawrence Grade 2, 3, or 4 (in select subjects who have no bony deformity) knee OA on most recent knee radiograph obtained within 6 months of screening visit;
• Knee pain resistant to conservative treatment for at least 3 months (anti- inflammatory drugs, acetaminophen, physical therapy, muscle strengthening, or intra- articular injection of hyaluronic acid and/or steroids);
• Moderate to severe knee pain: pain VAS ≥ 40 mm with 0 representing 'no pain' and 100 'the worst pain imaginable. If both knees meet inclusion criteria, the one with a higher VAS score will be chosen for the study (i.e., target knee).
• Willing, able, and mentally competent to provide informed consent and complete study questionnaires in English. The Study questionnaire is validated in English.

Exclusion Criteria

• Active systemic or local knee infection;
• Active malignancy;
• Life expectancy less than 12 months;
• Prior ipsilateral knee surgery (within 3 years of baseline visit), arthroscopic surgery (within 6 months of baseline), total or partial knee replacement regardless of timing;
• Ipsilateral knee intra-articular injection in the last 3 months;
• Rheumatoid arthritis, spondyloarthropathies, crystal disease, gout, pseudogout, or lupus;
• Pregnant during the study period;
• Renal dysfunction as defined by serum creatinine >1.6 dl/mg or eGFR 1.5 within 30 days of procedure;
• Known history of contrast allergy resulting in anaphylaxis;
• Known significant arterial atherosclerosis that would limit selective angiography and/or lower extremity symptoms thought to be secondary to arterial vascular disease (eg claudication, ischemic rest pain);
• Post-traumatic knee (if trauma occurred within 12 months of baseline or was associated with fractures);
• Known avascular necrosis in the target knee;
• Contraindications to MRI such as such as claustrophobia, metallic fragment/implants, pacemaker.