N/A Completed N=77 Randomized Other

Stress, Emotion Regulation, and Alcohol in Women Veterans

Alcohol Use Disorder · Post-Traumatic Stress Disorder

Source: ClinicalTrials.gov NCT04393623 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Feb 2026

Primary outcomePrimary: Change in Alcohol Craving During Experimental Sessions — 2.87; 2.97; 3.18; 3.22 Units on a Scale — p=.94

Summary

The purpose of the study "Stress, Emotion Regulation, and Alcohol in Women Veterans" is to learn about the effects of negative emotion and stress on behavior (including alcohol use) among women Veterans, including women with and without posttraumatic stress disorder. Additionally, the study looks at whether a woman's use of emotion regulation techniques changes the association between stress or negative emotion and behavior. Lastly, the study examines how women's reactions to stress, and the effects of stress, vary across the menstrual cycle - depending on the level of circulating hormones.

Outcome Measures

Outcome	Result	p-value
PRIMARY Change in Alcohol Craving During Experimental Sessions	2.87; 2.97; 3.18; 3.22; 3.27; 3.24	.94
PRIMARY Change in Heart Rate Variability (HRV) During Experimental Sessions	47.20; 36.64; 108.33; 34.82; 62.69; 40.68	—
PRIMARY Change in Frequency of Alcohol Use Prior to and Through Study Completion	46.49; 45.91; 54.57; 47.15	—
PRIMARY Change in Intensity of Alcohol Use Prior to and Through Study Completion	2.98; 2.42; 2.63; 2.37	—

Eligibility Criteria

Inclusion Criteria

Current alcohol misuse, defined as scoring 3 or higher on the AUDIT-C
If using other illicit substances, alcohol is their primary substance of use
Alcohol use in the past 45 days
Able to write and speak in English
Served in the U.S. Military
Willing to provide blood samples at laboratory sessions to assay hormone levels and take urine ovulation tests at home

Exclusion Criteria

Psychotic symptoms or uncontrolled Bipolar Disorder (screened for during session 1 using SCID-5 screening modules)
Brain damage or were in an accident that affects ability to complete the computerized task
Current (past 3 months) active suicidal ideation or intent
Current pregnancy

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT04393623). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.