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N/A N=77 Randomized Other

Stress, Emotion Regulation, and Alcohol in Women Veterans

Alcohol Use Disorder · Post Traumatic Stress Disorder

Bottom Line

View on ClinicalTrials.gov: NCT04393623 ↗
Enrolled (actual)
77
Serious AEs
0.0%
Results posted
Feb 2026
Primary outcome: Primary: Change in Alcohol Craving During Experimental Sessions — 2.87; 2.97; 3.18; 3.22 Units on a Scale — p=.94

Study Design & Population

Study type
Interventional
Phase
N/A
Interventions
Cognitive Reappraisal (Behavioral); Psychoeducation (Behavioral)
Age
Adult, Older Adult · 18+ yrs
Sex
Female
Sponsor
VA Office of Research and Development
Primary completion
Sep 2024

Outcome Measures

OutcomeResultp-value
PRIMARY
Change in Alcohol Craving During Experimental Sessions		 2.87; 2.97; 3.18; 3.22; 3.27; 3.24 .94
PRIMARY
Change in Heart Rate Variability (HRV) During Experimental Sessions		 47.20; 36.64; 108.33; 34.82; 62.69; 40.68 —
PRIMARY
Change in Frequency of Alcohol Use Prior to and Through Study Completion		 46.49; 45.91; 54.57; 47.15 —
PRIMARY
Change in Intensity of Alcohol Use Prior to and Through Study Completion		 2.98; 2.42; 2.63; 2.37 —

Summary

The purpose of the study "Stress, Emotion Regulation, and Alcohol in Women Veterans" is to learn about the effects of negative emotion and stress on behavior (including alcohol use) among women Veterans, including women with and without posttraumatic stress disorder. Additionally, the study looks at whether a woman's use of emotion regulation techniques changes the association between stress or negative emotion and behavior. Lastly, the study examines how women's reactions to stress, and the effects of stress, vary across the menstrual cycle - depending on the level of circulating hormones.

Eligibility Criteria

Inclusion Criteria

  • Current alcohol misuse, defined as scoring 3 or higher on the AUDIT-C
  • If using other illicit substances, alcohol is their primary substance of use
  • Alcohol use in the past 45 days
  • Able to write and speak in English
  • Served in the U.S. Military
  • Willing to provide blood samples at laboratory sessions to assay hormone levels and take urine ovulation tests at home

Exclusion Criteria

  • Psychotic symptoms or uncontrolled Bipolar Disorder (screened for during session 1 using SCID-5 screening modules)
  • Brain damage or were in an accident that affects ability to complete the computerized task
  • Current (past 3 months) active suicidal ideation or intent
  • Current pregnancy
View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT04393623). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.

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