N/A
N=100
Self-Control in Bulimia Nervosa
Bulimia Nervosa
Bottom Line
View on ClinicalTrials.gov: NCT04409457 ↗Enrolled (actual)
100
Serious AEs
0.0%
Results posted
Jan 2026
Primary outcome: Primary: Brain Activation Associated With P(Stop) — 0.02; 0.11; 0.04; 0.05 BOLD Signal
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- fasting state (Other); fed state (Other); magnetic resonance imaging (Other)
- Age
- Adult · 18+ yrs
- Sex
- Female
- Sponsor
- Icahn School of Medicine at Mount Sinai
- Primary completion
- Nov 2024
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Brain Activation Associated With P(Stop) |
0.02; 0.11; 0.04; 0.05; -0.16; -0.06 | — |
| PRIMARY Brain Activation Associated With Prediction Errors (Unsigned) |
0.09; 0.13; 0.08; 0.09; 0.07; 0.11 | — |
| PRIMARY Brain Activation Associated With Prediction Errors (Signed) |
0.05; 0.07; 0.03; 0.02; 0.16; 0.16 | — |
| PRIMARY Brain Activation Associated With Successful Inhibition |
0.06; 0.11; 0.08; 0.06; 0.18; 0.21 | — |
| SECONDARY Stop Signal Reaction Time (SSRT) |
164.37; 151.70; 170.80; 166.58 | — |
| SECONDARY Stop Signal Task Inhibition |
57.29; 55.56; 53.12; 56.25 | — |
Summary
This study examines the influence of acute fasting and eating on self-control in adult females with and without bulimia nervosa (BN). Specifically, the study team is investigating whether differences in behavior and brain activation in response to computer tasks after fasting and after eating a meal could help to explain the symptoms of bulimia nervosa. Data will be collected using questionnaires and a technology called magnetic resonance imaging (MRI).
Eligibility Criteria
Inclusion Criteria
- Female
- Aged 18 to 35 years
- Currently between 85 and 130% of the expected weight for height
- Right-handed
- English-speaking
Additional Inclusion Criteria for Women with Bulimia Nervosa:
- Meet DSM-5 criteria for bulimia nervosa
Exclusion Criteria
- Medical instability
- Ongoing medical treatment, medical condition, or psychiatric disorder that may interfere with study variables or participation
- Shift work
- Pregnancy, planned pregnancy, or lactation during the study period
- Allergy to any of the ingredients in or unwillingness to consume the standardized meal or unwillingness to drink water during the fasting period
- Any contraindication for fMRI
Data sourced from ClinicalTrials.gov (NCT04409457). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.