N/A
N=5,446
Best Practice Alert for Opioid Prescribing
Opioid Use
Bottom Line
View on ClinicalTrials.gov: NCT04446975 ↗Enrolled (actual)
5,446
Serious AEs
—
Results posted
Mar 2024
Primary outcome: Primary: Opioids Prescribed at Discharge — 100; 75 miligram morphine equivalents
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- BPA (Other)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- University of Colorado, Denver
- Primary completion
- Jun 2021
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Opioids Prescribed at Discharge |
100; 75 | — |
| SECONDARY Number of Participants With Opioid/Non-opioid Combination Medications Prescribed on Day of Discharge |
1758; 1687 | — |
| SECONDARY Number of Participants With Opioid Prescriptions After Discharge |
1870; 2046 | — |
Summary
The investigators will embed a developed decision support tool into the electronic health record (EHR) to individualize pain therapy in surgical patients after hospital discharge and test its performance in a pragmatic clinical trial.
Preliminary data indicate that current opioid prescription practice after surgery follows a "one size fits all" pattern. In-hospital opioid use prior to discharge serves as a reliable indicator to estimate needs for analgesic medications at home. The investigators will test the hypothesis that the existing tool will enable providers to write need-based prescriptions based on prior-to-discharge opioid use, empower patients to maximize alternatives to opioids (ALTO) therapies at home, while minimizing the need for rescue prescriptions. The investigators will test this tool prospectively in a cohort of ~1,000 providers (primary subjects) and ~39,000 surgical patients (secondary subjects) in four University of Colorado Health (UCHealth) hospitals (clusters to be exposed versus (vs.) non-exposed to the intervention).
Eligibility Criteria
Inclusion Criteria
Primary subjects:
- Credentialed providers (attending, fellow, and resident physicians, advanced practice providers including nurse practitioners and physician assistants) at each UCH (UC Health) site writing a discharge opioid prescription are eligible to receive the intervention.
Secondary subjects:
- Adult surgical inpatients age 18 and older within the UCHealth system at 4 different hospitals including UCH Metro, UCH Memorial Central, Medical Center of the Rockies, and Poudre Valley Hospital.
Exclusion Criteria
Primary subjects:
- None
Secondary subjects:
- Less than 18 years of age.
Data sourced from ClinicalTrials.gov (NCT04446975). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.