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N/A N=99 Randomized Basic Science

Adolescent Responses to Varying Environments in Virtual Reality Simulations

Residential Characteristics · Emotions · Stress, Psychological · Stress, Physiological

Enrolled (actual)
99
Serious AEs
0.0%
Results posted
Jun 2024
Primary outcome: Primary: Emotional Response — 3.65; 4.31; 1.29; 0.33 units on a scale

Study Design & Population

Study type
Interventional
Phase
N/A
Interventions
Virtual reality (Other)
Age
Pediatric · 14+ yrs
Sex
All
Sponsor
University of Southern California
Primary completion
Apr 2023

Outcome Measures

OutcomeResultp-value
PRIMARY
Emotional Response
3.65; 4.31; 1.29; 0.33; 2.98; 4.54
PRIMARY
Salivary Cortisol
0.121; 0.135; 0.134; 0.182; 0.251; 0.287
PRIMARY
Blood Pressure
120.45; 117.79; 123.82; 125.97; 120.41; 114.11
PRIMARY
Respiratory Sinus Arrhythmia (RSA)
6.56; 6.31; 6.88; 6.69; 6.77; 6.65
PRIMARY
Cardiac Output (CO)
5.35; 5.50; 5.37; 5.90; 5.18; 5.29
PRIMARY
Total Peripheral Resistance (TPR)
18.82; 19.29; 19.62; 18.05; 18.29; 18.04
PRIMARY
Pre-ejection Period (PEP)
114.69; 117.92; 112.49; 113.84; 112.97; 114.60

Summary

The objective of this study, named THRIVE (The Research In Virtual Environments Study), is to test hypotheses for how neighborhood environments influence stress and emotion, as a mechanism by which they may influence health. Neighborhood environments may have both acute influences on stress-related processes, but also may have lifespan effects due to the chronic, cumulative effects of repeated exposures and the long-term toll of adapting to adverse neighborhood environments. However, assessing neighborhood influences on stress and emotion is methodologically challenging. This study develops such a novel, alternative approach to address these questions by deploying a virtual reality (VR) based model of neighborhood disadvantage and affluence that creates an immersive experience approximating the experience of being in different neighborhoods. In this study, this model will be applied to understand neighborhood effects in a diverse sample of adolescents (n = 130) from a range of disadvantaged and affluent neighborhoods. The proposed study will employ a randomized experiment (n = 65 per condition), with online questionnaires and a single study session, to determine (a) if virtual exposure to neighborhood disadvantage elicits differences in emotion and stress reactivity; (2) if growing up in a disadvantaged neighborhood results in habituation or sensitization to different neighborhood characteristics; and (3) if chronic stress results in habituation or sensitization to different neighborhood characteristics. This research will develop an innovative methodology that will help establish the role that neighborhoods may play in eliciting stress as well as the processes of adaptation to chronic stress and chronic neighborhood exposures. In addition, it will help establish a method that can be utilized more broadly to study contextual and social environmental influences on psychological and biological risk in adolescence.

Eligibility Criteria

Inclusion Criteria

  • English speaking
  • Are able to use a dominant hand for joystick manipulation and a non- dominant hand for physiological measurements,
  • Are in good physical and mental health, with no self-reported history of hypertension, cardiovascular disease (CVD) or CVD treatment (with associated medication list indicative of treatments that result in exclusion),
  • Have hair at least 1cm in length based on self-report to be able to provide a hair sample.

Exclusion Criteria

  • Pregnant, by self-report
View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT04465240). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.

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