N/A N=59 Randomized Single-blind Treatment

Mnemonic Strategy Versus Spaced Retrieval Training in Those With Mild Cognitive Impairment

Mild Cognitive Impairment

Bottom Line

View on ClinicalTrials.gov: NCT04533204 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Mar 2021

Primary outcome: Primary: Percent of Correct Object Location Associations Assessed up to 1 Month Post-treatment — 80.0; 62.45 percent correct — p=<.001

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: mnemonic strategy training (Behavioral); spaced retrieval training (Behavioral)
Age: Pediatric, Adult, Older Adult
Sex: All
Sponsor: VA Office of Research and Development
Primary completion: Jun 2014

Outcome Measures

Outcome	Result	p-value
PRIMARY Percent of Correct Object Location Associations Assessed up to 1 Month Post-treatment	80.0; 62.45	<.001 sig
SECONDARY Change in Accuracy (vs. Baseline) on Novel Object Location Associations	6.1; 7.14	.004 sig

Summary

This study compared two active cognitive interventions to evaluate whether one improved memory more than the other in patients with mild cognitive impairment. Participants were randomized to either memory strategy training or spaced retrieval training and completed memory tests before and after 3 training sessions. Participants returned 1 month after treatment to see how well they remembered the learned information. Brain scans (functional MRI) were collected before and after the interventions to see if training changed the way brain regions were functioning.

Eligibility Criteria

Inclusion Criteria

-Diagnosis of MCI according to Petersen (2004) criteria, right handed

Exclusion Criteria

Diagnosis of other neurological condition,
active drug/alcohol abuse/dependence,
moderate-severe depression or other Axis I diagnoses.

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT04533204). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.