N/A
N=52
Prolonged Prone Positioning for COVID-19-induced Acute Respiratory Distress Syndrome (ARDS)
ARDS · Covid19 · Acute Hypoxemic Respiratory Failure
Bottom Line
View on ClinicalTrials.gov: NCT04581811 ↗Enrolled (actual)
52
Serious AEs
0.0%
Results posted
Mar 2022
Primary outcome: Primary: Duration in Prone Position — 56.6; 45.7 hours
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Prolonged Proned Positioning (Other); Traditional Proning Arm (Other)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- University of Alabama at Birmingham
- Primary completion
- Mar 2021
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Duration in Prone Position |
56.6; 45.7 | — |
| SECONDARY Change in P:F Ratio |
46.6; 44.3 | — |
| SECONDARY Change in Drive Pressure |
0.16; 0.88 | — |
| SECONDARY Unplanned Extubations |
0; 1 | — |
| SECONDARY Pressure Ulcers |
1; 0 | — |
| SECONDARY Line Displacement |
0; 1 | — |
| SECONDARY Vent Free Days |
6.27; 5.81 | — |
| SECONDARY Mortality |
14; 15 | — |
| SECONDARY Rescue Interventions |
0; 1 | — |
| SECONDARY Tracheostomy |
6; 3 | — |
| SECONDARY ICU Free Days |
4.35; 4.15 | — |
| SECONDARY S:F Ratio |
1.70; 1.69 | — |
Summary
Prone positioning is one of the few therapies known to improve mortality in ARDS. Traditionally, patients are proned for 16 hours per 24 hour period. Some retrospective data suggests improvement may persist beyond 16 hours. We aim to perform a pilot study comparing traditional prone positioning to prolonged prone positioning in patients with COVID-induced ARDS.
Eligibility Criteria
Inclusion Criteria
Positive COVID test Endotracheal Intubation P:F 48 hours prior to initiation of prone positioning Contraindication to proning Physician discretion
Data sourced from ClinicalTrials.gov (NCT04581811). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.