N/A
Completed N=31
LIFUP for Treatment of Motor Deficits in Parkinson's Disease
Source: ClinicalTrials.gov NCT04593875 ↗Enrolled (actual)
31
Serious AEs
0.0%
Results posted
Feb 2026
Primary outcomePrimary: Motor Assessment 1: Unified Parkinson Disease Rating Scale (UPDRS) Section 3 — 37.24; 35.14; 36.93; 34.21 score on a scale
Summary
The study will test the feasibility of using Low Intensity Focused Ultrasound Pulsation (LIFUP) to treat motor symptoms in Parkinson's Disease (PD). LIFUP is a new technique that can increase brain activity in highly specific target areas and is MRI compatible. Thus, in real-time, it is possible to directly observe how LIFUP changes the brain areas important in PD by measuring its effects on brain activity, blood flow, and brain connectivity. If successful, this research will mark the first step towards a novel, non-invasive, non-medication treatment for PD.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Motor Assessment 1: Unified Parkinson Disease Rating Scale (UPDRS) Section 3 |
37.24; 35.14; 36.93; 34.21 | — |
| PRIMARY Motor Assessment 2: Finger Tapping (Score) |
1.48; 1.45; 1.66; 1.34 | — |
| PRIMARY Motor Assessment 2: Finger Tapping (Speed) |
1.81; 1.72; 1.70; 1.94 | — |
| PRIMARY Motor Assessment 2: 9-Hole Pegboard Dexterity Test |
23.87; 23.94; 23.49; 23.12; 21.04; 20.73 | — |
| SECONDARY Difference in BOLD fMRI Signal Between on vs. Off Blocks |
1.19; 0.41 | — |
| SECONDARY Perfusion Changes in Internal Globus Pallidus, External Globus Pallidus, and Putamen |
16.4; 17.0; 30.0; 16.6; 28.4; 14.0 | — |
Eligibility Criteria
Inclusion Criteria
- Diagnosis of Parkinson's disease
- Age 18-85
- Fluent in the English language
Exclusion Criteria
- Metal implants that are not MR compatible
- Neurological diagnosis other than Parkinson's
- Not fluent in the English language
Data sourced from ClinicalTrials.gov (NCT04593875). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.