N/A
N=37
Pleural Manometry for the Characterization of Spontaneous and Tension Pneumothorax
Pneumothorax · Tension Pneumothorax
Bottom Line
View on ClinicalTrials.gov: NCT04630301 ↗Enrolled (actual)
37
Serious AEs
0.0%
Results posted
Aug 2025
Primary outcome: Primary: Pleural Pressure (Ppl) Prior to Evacuation of Pleural Air — 7.44; -1.79 cmH2O
Study Design & Population
- Study type
- Observational
- Phase
- N/A
- Interventions
- —
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- Johns Hopkins University
- Primary completion
- Jun 2025
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Pleural Pressure (Ppl) Prior to Evacuation of Pleural Air |
7.44; -1.79 | — |
| SECONDARY Duration (Days) of Chest Tube Placement |
4.30303 | — |
| SECONDARY Referral for Pleurodesis |
1; 4 | — |
| SECONDARY Intrabronchial Valve (IBV) Placement |
3 | — |
| SECONDARY Referral for Video Assisted Thoracoscopic Surgery (VATS) |
1 | — |
Summary
Intrapleural pressures have been shown to be a useful clinical predictor in pleural effusions, however it's utility has not been described in pneumothorax. Data on intrapleural pressures in pneumothorax are limited. Furthermore, the pleural pressure in tension pneumothorax is theorized to be greater than atmospheric pressure, though this has never been verified. Pneumothorax is primarily treated with a tube thoracostomy. This observational study will record intrapleural pressures in participants with pneumothorax undergoing a tube thoracostomy. Clinical outcomes of participants will then be monitored for need for pleurodesis, intrabronchial valve placement, and video assisted thoracoscopic surgery (VATS) to identify a correlation with intrapleural pressure.
Eligibility Criteria
Inclusion Criteria
- patients aged 18 or older admitted to the Johns Hopkins Hospital with clinical or radiographic evidence of new pneumothorax who are referred to Interventional Pulmonology for needle aspiration or tube thoracostomy. TP will be defined as a pneumothorax that results in mean arterial pressure <65 or systolic BP < 90.
Exclusion Criteria
- bilateral pneumothorax
Data sourced from ClinicalTrials.gov (NCT04630301). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.