N/A N=40 Randomized Double-blind Prevention

Piloting the IPROACTIF Program to Preserve Functioning and Prevent Cognitive Decline

Heart Disease (Coronary Artery Disease, Ischemic Heart Disease, Hypertensive Heart Disease) · Uncontrolled Diabetes (HBA1c ≥ 10)

Bottom Line

View on ClinicalTrials.gov: NCT04682977 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Aug 2025

Primary outcome: Primary: Physical Functioning Measured Using the Patient-Specific Functional Scale — 7.45; 5.43 score on a scale — p=0.04

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: IPROACTIF (Integrated PRimary Care and Occupational Therapy for Aging and Chronic Disease Treatment to preserve Independence and Functioning) (Other); Usual primary care services (Other)
Age: Adult, Older Adult · 55+ yrs
Sex: All
Sponsor: University of Illinois at Chicago
Primary completion: Mar 2024

Outcome Measures

Outcome	Result	p-value
PRIMARY Physical Functioning Measured Using the Patient-Specific Functional Scale	7.45; 5.43	0.04 sig
PRIMARY Physical Functioning Measured Using the PROMIS Physical Function Short Form 20	43.91; 40.79	0.26
PRIMARY Physical Functioning Measured Using the Physical Performance Test (9-item)	24.7; 25.4	0.51
SECONDARY Participation in Life Activities and Roles Using the Late Life Functioning and Disability Index (Disability Component) - Frequency Dimension	52.01; 50.30	0.23
SECONDARY Participation in Life Activities and Roles Using the Late Life Functioning and Disability Index (Disability Component) - Limitations Dimension	74.70; 70.41	0.44
SECONDARY Health Related Quality of Life Using the PROMIS Global Health Measure (Physical Subscale)	48.36; 43.21	0.22
SECONDARY Health Related Quality of Life Using the PROMIS Global Health Measure (Mental Subscale)	45.71; 46.38	0.91
SECONDARY Self-efficacy Measured Using the Doing Chores Scale From the Self-Management Resource Center	8.14; 6.98	0.78
SECONDARY Self-efficacy Measured Using the Manage Symptoms Scale From the Self-Management Resource Center	7.30; 7.18	0.83
SECONDARY Self-efficacy for Chronic Disease Management Using the Obtain Help From Community, Family, Friends Scale From the Self-Management Resource Center	0.10; 0.35	0.67
SECONDARY Self-efficacy for Chronic Disease Management Using the Manage Disease in General Scale From the Self-Management Resource Center	0.20; 0.00	0.77
SECONDARY Self-efficacy for Chronic Disease Management Using the Social Recreational Activities Scale From the Self-Management Resource Center	0.02; 0.50	0.79
SECONDARY Self-efficacy for Chronic Disease Management Using the Exercise Regularly Scale From the Self-Management Resource Center	1.02; 0.24	0.44
SECONDARY Performance of Daily Living Tasks Using the Performance Assessment of Self-care Skills	0.09; 0.00	0.65
SECONDARY Executive Functioning Using the Executive Function Performance Test	1.70; 1.00	0.66
SECONDARY Executive Functioning Using the Dimensional Change Card Sort Test	4.00; 3.94	0.81
SECONDARY Physical Activity Level	-0.85; 0.07	0.89

Summary

Conduct a pilot randomized control to assess the preliminary efficacy of IPROACTIF, an occupational therapist-delivered primary care intervention for aging and chronic disease management.

Eligibility Criteria

Inclusion Criteria

English speaking
Community-dwelling
55 years of age
Primary diagnosis of heart disease (coronary artery disease, ischemic heart disease, hypertensive heart disease), or uncontrolled diabetes (HBA1c greater than/equal to 10)
Self-reported risk of functional decline (score of 3 or higher) on the 11-item Brief Risk Identification of Geriatric Health Tool or self-reported need for assistance with disease management

Exclusion Criteria

Current/past diagnosis of stroke or other neurological disorders
Receiving pharmacological treatment for cognition
Participating in other exercise or ADL-focused intervention studies
Non-English speaking
Residing in a long-term care institution
Compromised decision-making capacity (score >8 on SOMCT)

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT04682977). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.