N/A
N=15
Home-Based Exercise to Treat Decreased Physical Function in Patients With Varying Levels of Kidney Function
Chronic Kidney Disease
Bottom Line
View on ClinicalTrials.gov: NCT04745169 ↗Enrolled (actual)
15
Serious AEs
0.0%
Results posted
Aug 2025
Primary outcome: Primary: Change in Short Physical Performance Battery Score — -1 units on a scale — p=0.73
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- 8 week home-based exercise program (Behavioral)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- Baylor College of Medicine
- Primary completion
- Nov 2023
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Change in Short Physical Performance Battery Score |
-1 | 0.73 |
| SECONDARY Change in Grip Strength |
2.8 | 0.07 |
| SECONDARY Change in Gait Speed |
-0.1 | 0.65 |
| SECONDARY Change in Exhaustion |
10.0 | 0.31 |
| SECONDARY Change in Physical Activity |
-0.4 | 0.55 |
| SECONDARY Change in Quality of Life |
1.7 | 0.95 |
| SECONDARY Change in Weight |
-1.1 | 0.15 |
| SECONDARY Change in Percent Body Fat |
0.9 | 0.31 |
| SECONDARY Change in Physical Frailty Phenotype |
— | 0.37 |
Summary
The investigators will conduct a pilot study to determine whether home-based exercise is an effective intervention to improve decreased physical function in kidney transplant candidates. The investigators will determine if home-based exercise improves frailty parameters and SPPB scores. The investigators will also determine if home-based exercise improves health-related quality of life (HRQOL), physical activity, and adverse clinical outcomes, including hospitalizations.
Eligibility Criteria
Inclusion Criteria
- Age 18 years or older
- Consenting to research
- Chronic kidney disease (stages 1-5)
- An SPPB score ≤10 or considered frail or pre-frail according to the Fried Frailty Phenotype
Exclusion Criteria
- Younger than 18 years
- Patients being evaluated for combined organ transplantation
- Significant comorbidities that limit rehabilitation potential including pulmonary disease requiring continuous oxygen supplementation, active angina, critical aortic sclerosis, decompensated heart failure, or known ventricular arrhythmia.
- An SPPB score >10 or not considered frail or pre-frail by the Fried Frailty Phenotype
- Non-English speaker without availability of adequate interpreter services (safety concern)
- Failure to pass submaximal exercise test in patients not approved for kidney transplantation at our center
Data sourced from ClinicalTrials.gov (NCT04745169). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.