N/A
N=20
Direct Measurement of Motor Cortical Responses to tDCS
Parkinson Disease
Bottom Line
View on ClinicalTrials.gov: NCT04759898 ↗Enrolled (actual)
20
Serious AEs
0.0%
Results posted
May 2026
Primary outcome: Primary: Change in Primary Motor Cortex Beta-Band Spectral Power During Movement Preparation With Anodal tDCS — 12 log10(µV²/Hz)
Study Design & Population
- Study type
- Observational
- Phase
- N/A
- Interventions
- transcranial direct current stimulation (invasive recording) (Device)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- Medical University of South Carolina
- Primary completion
- Jan 2025
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Change in Primary Motor Cortex Beta-Band Spectral Power During Movement Preparation With Anodal tDCS |
12 | — |
Summary
Transcranial direct current stimulation (tDCS) has shown the potential to improve symptoms in patients with movement deficits, such as Parkinson's disease and chronic stroke. However, the effects of tDCS have so far not been proven on a wider scale due to lack of knowledge regarding exactly how tDCS works. This has limited the adoption of this potentially useful therapy for patients with Parkinson's disease, chronic stroke and other conditions affecting movement. The investigators hypothesize that by studying the effects of tDCS in subjects performing a motor task, the brain signals mediating improvements in motor control will be identified. The investigators will use both noninvasive and invasive methods to explore this hypothesis. The investigators expect this combined approach to broaden understanding of tDCS application in conditions affecting movement and possibly lead to therapeutic advances in these populations.
Eligibility Criteria
Inclusion Criteria
- Age 18 or older
- Previous consent to be contacted regarding potential participation in a research study at Medical University of South Carolina
Exclusion Criteria
- Subjects unable to actively participate in the consent process physically and/or cognitively
- Pregnancy
- Presence of scalp injury or disease
- Prior history of seizures
- Metal implants in head or neck
- Prior intracranial surgery
- Prior brain radiotherapy
- Prior history of intracranial tumor, intracranial infection or cerebrovascular malformation
Data sourced from ClinicalTrials.gov (NCT04759898). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.