N/A
N=30
Happy Older Latinos Are Active - Cognitive Decline
Cognitive Decline
Bottom Line
View on ClinicalTrials.gov: NCT04791709 ↗Enrolled (actual)
30
Serious AEs
0.0%
Results posted
Oct 2025
Primary outcome: Primary: Percentage of Participants Completing the Study — 90 Percentage of participants
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Happy Older Latinos are Active (HOLA) (Behavioral)
- Age
- Adult, Older Adult · 50+ yrs
- Sex
- All
- Sponsor
- University of Miami
- Primary completion
- Mar 2025
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Percentage of Participants Completing the Study |
90 | — |
| SECONDARY Changes in Neurocognitive Impairment as Measured by the Trails Making Test |
48.7; 172.0; 44.3; 137.0 | — |
| SECONDARY Changes in Neurocognitive Impairment as Measured by the WAIS-IV Digit Span |
6.5; 6.81 | — |
| SECONDARY Changes in Physical Activity as Measured by the Global Physical Activity Questionnaire (GPAQ) |
1,743; 4,533 | — |
| SECONDARY Changes in Depression as Measured by the PHQ-9 |
6.67; 4.26 | — |
| SECONDARY Changes in Anxiety as Measured by the GAD-7 |
4.83; 3.56 | — |
| SECONDARY Changes in Psychosocial Functioning as Measured by the MSPSS |
5; 5 | — |
| SECONDARY Changes in Biomarkers of Cognition |
6.6; 6.6; 3117.1; 3411.3; 34.1; 32.3 | — |
| SECONDARY Changes in Biomarkers of Cognition Levels |
39.9; 36.6; 79.4; 65.8 | — |
| SECONDARY Changes in Adiponectin |
13999.1; 14289.6 | — |
Summary
The purpose of this study is to look at the best ways to prevent cognitive decline (loss of memory and/or functioning) in midlife and older Latino adults living with HIV.
Eligibility Criteria
Inclusion Criteria
- are Latino (self-identified);
- are age 50+;
- are HIV infected but are virologically suppressed (viral load <200 copies/mL);
- volunteer informed consent
Exclusion Criteria
- have diagnosis of any neurodegenerative disorder or dementia (Parkinson's disease, Alzheimer's disease, vascular, frontotemporal dementia, etc.) or significant cognitive impairment as indicated by a Telephone Interview for Cognitive Status (TICS) score less than or equal to 30;
- have other conditions that could impact cognitive functioning or testing (e.g., legally blind or deaf), currently undergoing radiation or chemotherapy, a history of brain trauma with a loss of consciousness greater than 30 minutes.
- have contraindications to physical activity outlined in the American College of Sports Medicine standards or severe medical illness that precludes them from safely participating in a health promotion intervention.
- are unable to complete 10-meter walk test.
- have plans to move outside of the Miami metropolitan area within the next 6 months or are not living in stable housing (e.g. group home).
Data sourced from ClinicalTrials.gov (NCT04791709). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.