N/A
N=3,228
Comparing Smoking Cessation Interventions Among Underserved Patients Referred for Lung Cancer Screening
Smoking Cessation
Bottom Line
View on ClinicalTrials.gov: NCT04798664 ↗Enrolled (actual)
3,228
Serious AEs
—
Results posted
Feb 2026
Primary outcome: Primary: Biochemically Confirmed Smoking Abstinence Sustained for 6 Months — 26; 45; 78; 61 Participants — p=0.797
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Removal of Financial Barriers (Behavioral); Financial Incentives (Behavioral); Mobile Health Application (Behavioral)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- Abramson Cancer Center at Penn Medicine
- Primary completion
- Nov 2024
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Biochemically Confirmed Smoking Abstinence Sustained for 6 Months |
26; 45; 78; 61 | 0.797 |
| SECONDARY Quit Status (Biochemically Confirmed) |
58; 85; 133; 90; 37; 56 | 0.971 |
| SECONDARY Health-related Quality of Life |
10.3; 9.90; 9.33; 9.69; 0.612; 0.645 | — |
| SECONDARY Perceived Barriers to Cessation |
45.0; 45.5; 43.1; 44.0; 22.4; 22.5 | — |
| SECONDARY Self-efficacy Related to Cessation Efforts |
26.8; 27.4; 28.8; 27.9 | — |
| SECONDARY Motivation to Quit |
12; 17; 16; 11; 104; 144 | — |
| SECONDARY Temporal ("Delay") Discounting |
2.33; 1.79; 1.64; 1.47 | — |
| SECONDARY Health-related Quality of Life |
10.3; 9.90; 9.33; 9.69; 0.612; 0.645 | — |
| SECONDARY Perceived Barriers to Cessation |
45.0; 45.5; 43.1; 44.0; 22.4; 22.5 | — |
| SECONDARY Self-efficacy Related to Cessation Efforts |
26.8; 27.4; 28.8; 27.9 | — |
| SECONDARY Motivation to Quit |
12; 17; 16; 11; 104; 144 | — |
| SECONDARY Temporal ("Delay") Discounting |
2.33; 1.79; 1.64; 1.47 | — |
| SECONDARY Health-related Quality of Life |
10.3; 9.90; 9.33; 9.69; 0.612; 0.645 | — |
| SECONDARY Perceived Barriers to Cessation |
45.0; 45.5; 43.1; 44.0; 22.4; 22.5 | — |
| SECONDARY Self-efficacy Related to Cessation Efforts |
26.8; 27.4; 28.8; 27.9 | — |
| SECONDARY Motivation to Quit |
12; 17; 16; 11; 104; 144 | — |
| SECONDARY Temporal ("Delay") Discounting |
2.33; 1.79; 1.64; 1.47 | — |
| SECONDARY Self-report Cigarette Abstinence |
84; 130; 172; 129; 46; 66 | 0.730 |
| SECONDARY Self-report Other Tobacco Abstinence |
81; 130; 169; 127; 46; 65 | 0.559 |
Summary
To compare the effectiveness of four interventions to promote sustained, biochemically confirmed smoking abstinence for 6 months among underserved smokers referred for lung cancer screening at four large U.S. health systems.
Eligibility Criteria
Inclusion Criteria
- Current smoker (≥ 1 cigarettes per day, not including e-cigarettes)
- Has a low-dose computed tomography (LDCT) scan ordered by their physician
- Underserved, defined as one or more of the following: (a) Black, (b) Hispanic, (c) rural residence, or (d) low socioeconomic status (Defined as one or both of: high-school education or less, or household income <200% of the federal poverty line)
- Able to receive study invitation and screening, by virtue of showing up to a radiology location affiliated with a participating health system for the LDCT, or having a valid email address or telephone number on file with the health system
- Access to a cell phone with text messaging or the internet
- Aged 18 years or older
Exclusion Criteria
- No cell phone
Data sourced from ClinicalTrials.gov (NCT04798664). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.