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N/A N=37 Treatment

Online Singing Interventions for Postnatal Depression in Times of Social Isolation: a Single Arm Study

Postnatal Depression · Social Isolation

Enrolled (actual)
37
Serious AEs
0.0%
Results posted
Nov 2025
Primary outcome: Primary: To Assess the Effectiveness of Online Group Singing Interventions on Symptoms of Postnatal Depression Using the Edinburgh Postnatal Depression Scale (EPDS) — 16.6; 11.2 score on a scale — p=.001

Study Design & Population

Study type
Interventional
Phase
N/A
Interventions
Melodies for Mums (Behavioral)
Age
Adult, Older Adult · 18+ yrs
Sex
Female
Sponsor
King's College London
Primary completion
Mar 2022

Outcome Measures

OutcomeResultp-value
PRIMARY
To Assess the Effectiveness of Online Group Singing Interventions on Symptoms of Postnatal Depression Using the Edinburgh Postnatal Depression Scale (EPDS)
16.6; 11.2 .001 sig
SECONDARY
To Assess Whether Online Singing Improves (Changes) Further Aspects of Mental Health, Including Depression Using the Hamilton Depression Rating Scale (HDRS)
13.8; 7.4
SECONDARY
To Assess Whether Online Singing Improves (Changes) Further Aspects of Mental Health, Including Depression Using the Beck Depression Inventory (BDI).
18.9; 15.1; 13.0; 12.3; 11.6
SECONDARY
To Assess Whether Online Singing Improves (Changes) Further Aspects of Mental Health, Including Stress Using the Perceived Stress Scale (PSS)
29.0; 22.4; 19.7; 19.2; 19.1
SECONDARY
To Assess Whether Online Singing Improves (Changes) Further Aspects of Mental Health, Including Wellbeing Using the Office for National Statistics Wellbeing Scale (ONS):
50.0; 72.8; 51.7; 78.6
SECONDARY
To Assess Whether Online Singing Improves (Changes) Further Aspects of Mental Health, Including Anxiety, Using the State-Trait Anxiety Scale (STAI)
48.4; 41.7; 37.1; 37.9; 37.2
SECONDARY
To Ascertain Whether Online Singing Improves the Observed Mother-infant Interaction Using the Crittenden CARE-Index (CCI)
SECONDARY
To Ascertain Whether Online Singing Improves the Perceived Mother-infant Relationship Using the Maternal Postpartum Attachment Scale (MPAS)
SECONDARY
To Ascertain Whether Online Singing Improves the Perceived Mother-infant Relationship Using the Parent Reflective Functioning Questionnaire (PRFQ)
SECONDARY
To Ascertain Whether Online Singing Improves Social Support and Reduces Loneliness Using the UCLA Loneliness Scale
SECONDARY
To Ascertain Whether Online Singing Improves Social Support and Reduces Loneliness Using the Multidimensional Scale of Perceived Social Support (MSPSS)
SECONDARY
To Identify Whether There Are Biological Mechanisms Underpinning the Psychological Outcomes Assessed Using Changes in Measurements in Stress Hormones, Including Diurnal Cortisol and Salivary Cytokines
SECONDARY
To Identify Whether There Are Biological Mechanisms Underpinning the Psychological Outcomes Assessed Using Changes in Measurements in Salivary Oxytocin
SECONDARY
To Identify How the Online Singing Sessions Affect the Lived Experience of Mothers With PND Using Focus Groups
SECONDARY
To Explore the Phenomenology of PND and How Singing Intersects With PND Among Women With Particular Risk Factors for PND (Traumatic Birth, Adverse Childhood Experiences, and Social Isolation/Loneliness) Using Semi-structured Interviews

Summary

Melodies for Mums (M4M) is an intervention developed and tested as part of a collaboration between the Royal College of Music, Imperial College London and University College London from 2015-2017. The programme involved weekly singing classes for mothers and babies delivered in groups of 8-12 participants in Children's Centres for 10 weeks. M4M was tested in a three-arm RCT involving 134 mothers with PND (with an Edinburgh Postnatal Depression Scale (EPDS) score above 10), compared with a comparison group (10 weeks of creative play classes) or care as usual (wait-list control). The study found that mothers with moderate-severe symptoms of PND who participated in the programme with their baby had a significantly faster improvement in symptoms than mothers in usual care. Specifically, the mothers in the singing group had an average EPDS score of 15.7 at baseline (moderate depression), which dropped to 10.3 by week 6 and 9.4 by week 10. This improvement equated to an average 35% decrease in depressive symptoms across the first 6 weeks, by which point 65% of the singing group no longer had an EPDS above 13. While funding has been secured to upscale this intervention as part of the SHAPER-PND programme, funded by the Wellcome Trust, the recent lockdown has not only halted the programme in its face-to-face format, but also prompted the interest in developing an online version that can be used (1) if the requirement for social distancing, even when the lockdown is relaxed, makes impossible the delivery of the programme; and (2) to broaden the reach to a nationwide delivery and extending to a wider population that may not have been able to attend in-person sessions due to geographical constraints or severity of symptoms. M4M online is a 6-week intervention for mothers with PND. The original M4M programme would be delivered face-to-face in groups of 8-12 mothers in weekly sessions lasting one hour. However, due to the current situation with COVID-19, we will therefore modify the original face-to-face intervention for this online study, as follows: * Groups of around 15-17 women to ensure that all participants can be visible on one screen during online delivery to create a stronger community and connection * Offer 6 weeks of intervention, also building on the evidence from the face-to-face intervention that by 6 weeks there is already a significant improvement in depressive symptoms compared with control interventions * Introduce a two-week lead-in period before the beginning of the six-session course, where mothers will be able to use WhatsApp and at least one (monitored) Zoom session to get to know each other.

Eligibility Criteria

Inclusion Criteria

  • Women aged 18 or older
  • Satisfactory understanding of English
  • Women who have a child between 0 and up to 9 months old
  • Women with postnatal depression diagnosed using symptoms of PND at a minimum score of 10 on the EPDS.

Exclusion Criteria

The participant may not enter the study if ANY of the following apply:

  • Child outside of the age-range specified
  • Unable to give informed consent
  • Unable
View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT04857593). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.

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