N/A N=19 Treatment

Feasibility of Pain Informed Movement for Knee OA

Knee Osteoarthritis

Bottom Line

View on ClinicalTrials.gov: NCT04954586 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Oct 2024

Primary outcome: Primary: Acceptability of Content — 13 Participants

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: Pain Informed Movement (Other)
Age: Adult, Older Adult · 40+ yrs
Sex: All
Sponsor: McMaster University
Primary completion: Oct 2022

Outcome Measures

Outcome	Result	p-value
PRIMARY Acceptability of Content	13	—
PRIMARY Acceptability of Frequency	13	—
PRIMARY Acceptability of Duration	11	—
PRIMARY Burden of Questionnaires	14	—
PRIMARY Burden of Physical Tests	14	—
PRIMARY Recruitment Rate	19	—
PRIMARY Follow-Up Rate	14	—
PRIMARY Self Reported Adverse Events	14	—
PRIMARY Exercise Completion	13	—
PRIMARY Adherence	204	—
PRIMARY Recommending the Program	13	—
PRIMARY Using the Treatment Again	13	—
SECONDARY Change in Pain Modulation	0.28	—
SECONDARY Change in Pain Intensity - Past 24 Hours	-1.86	—
SECONDARY Change in Function	24.86	—
SECONDARY Change in Brain-derived Neurotrophic Factor	-2.36	—
SECONDARY Change in Pain Catastrophizing	-6.79	—
SECONDARY Change in Chronic Pain Self-efficacy	1.54	—
SECONDARY Change in Physical Performance Tests	4.71	—
SECONDARY Change in Anxiety and Depression	0.43	—
SECONDARY Change in Perspectives on Knee Replacement Surgery 1	4	—
SECONDARY Change in Perspectives on Knee Replacement Surgery 2	—	—
SECONDARY Change in Perspectives on Knee Replacement Surgery 3	3	—
SECONDARY Change in Pain	21.77	—

Summary

The pain experience and its associated mechanisms in people with knee osteoarthritis (OA) are known to be complex and multidimensional. The current understanding of OA pain mechanisms is incomplete, resulting in limited pain management strategies. There is high-quality evidence that suggests the use of exercise for people with knee OA can provide a reduction in pain, changes in quality of life, and have modest improvements in physical function. There is promising evidence to support that yoga for those with knee OA may improve pain intensity, function, and stiffness. The aim of this study is to establish the feasibility of a pain informed movement program, in addition to education for improving pain modulation. The data collected will be used to inform a pilot and feasibility randomized controlled trial (RCT) prior to a multi site RCT to assess the program's effectiveness with the primary outcome of change in pain severity mediated by change in descending modulation.

Eligibility Criteria

Inclusion Criteria

40 years of age and over
Have a diagnosis of knee OA by a physician
or fulfill the NICE criteria for knee OA diagnosis
Have an average pain intensity of ≥3/10 on a numeric pain scale

Exclusion Criteria

Cannot communicate in English
Have inflammatory arthritis or other systemic conditions
Have had lower limb trauma
Had surgery within the past 6-month, have participated in a similar knee OA exercise program in the prior 3-months
Have used oral corticosteroids or had a corticosteroid injection in the index knee within 6-months prior to baseline assessment.
Does not have access to the internet

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT04954586). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.