N/A Completed N=37 Randomized Single-blind Prevention

Sound and Music for Mild Cognitive Impairment

Source: ClinicalTrials.gov NCT05064007 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Aug 2025

Primary outcomePrimary: Episodic Memory Assessed by the Cogstate Alzheimer's Battery — -0.0746; 0.0700; 0.0593; 0.5137 z score

Summary

Emerging studies in humans found that 40 Hz sound induces neural gamma oscillation and enhanced cognitive function in older adults with and without Alzheimer's Disease. We will compare a 40 Hz music intervention to both 40 Hz sound and music alone in a clinical cohort of older adults with mild cognitive impairment.

Outcome Measures

Outcome	Result	p-value
PRIMARY Episodic Memory Assessed by the Cogstate Alzheimer's Battery	-0.0746; 0.0700; 0.0593; 0.5137; 0.553; 0.1614	—
PRIMARY Global Cognition Assessed by the Cogstate Alzheimer's Battery	8.3831; 5.5993; 15.3345; 18.6907; 16.2249; 10.4428	—

Eligibility Criteria

Inclusion Criteria

Community-dwelling
amnesia mild cognitive impairment
Preserved function
No dementia

Exclusion Criteria

known diagnosis of schizophrenia or Parkinson's disease;
severe hearing impairment;
presence of an acute medical or psychiatric condition which would interfere with the subject's ability to follow the study protocol realistically

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT05064007). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.