N/A
N=37
Sound and Music for Mild Cognitive Impairment
Mild Cognitive Impairment
Bottom Line
View on ClinicalTrials.gov: NCT05064007 ↗Enrolled (actual)
37
Serious AEs
0.0%
Results posted
Aug 2025
Primary outcome: Primary: Episodic Memory Assessed by the Cogstate Alzheimer's Battery — -0.0746; 0.0700; 0.0593; 0.5137 z score
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- A: 40 Hz music (Behavioral); B: 40 Hz sound (Behavioral); C: Preferred music (Behavioral)
- Age
- Adult, Older Adult · 50+ yrs
- Sex
- All
- Sponsor
- Johns Hopkins University
- Primary completion
- Apr 2024
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Episodic Memory Assessed by the Cogstate Alzheimer's Battery |
-0.0746; 0.0700; 0.0593; 0.5137; 0.553; 0.1614 | — |
| PRIMARY Global Cognition Assessed by the Cogstate Alzheimer's Battery |
8.3831; 5.5993; 15.3345; 18.6907; 16.2249; 10.4428 | — |
Summary
Emerging studies in humans found that 40 Hz sound induces neural gamma oscillation and enhanced cognitive function in older adults with and without Alzheimer's Disease. We will compare a 40 Hz music intervention to both 40 Hz sound and music alone in a clinical cohort of older adults with mild cognitive impairment.
Eligibility Criteria
Inclusion Criteria
- Community-dwelling
- amnesia mild cognitive impairment
- Preserved function
- No dementia
Exclusion Criteria
- known diagnosis of schizophrenia or Parkinson's disease;
- severe hearing impairment;
- presence of an acute medical or psychiatric condition which would interfere with the subject's ability to follow the study protocol realistically
Data sourced from ClinicalTrials.gov (NCT05064007). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.