Phase 4
Completed N=72
Intrathecal Morphine for Cesarean Delivery
Source: ClinicalTrials.gov NCT05069012 ↗Enrolled (actual)
72
Serious AEs
0.0%
Results posted
Nov 2025
Primary outcomePrimary: Duration of Pain Relief — 24.5; 29.4; 32 hours
◆ Published Evidence
Emerging
13citations · ~7 / year
A randomized controlled trial of spinal morphine with an enhanced recovery pathway and its effect on duration of analgesia after cesarean delivery.
Summary
This is a randomized double blinded non-inferiority study comparing the duration of pain relief when patients receive one of three doses of spinal morphine. Enrolled patients will be randomly assigned to receive either 50 mcg, 150 mcg, or 250 mcg. All patients will receive standardized postoperative care, including multimodal analgesia. The primary outcome will be the time until the patient requests additional opioid pain medications.
Linked Publications
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A randomized controlled trial of spinal morphine with an enhanced recovery pathway and its effect on duration of analgesia after cesarean delivery.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Duration of Pain Relief |
24.5; 29.4; 32 | — |
| SECONDARY Pain Scores |
2.2; 1.8; 1.9 | — |
| SECONDARY Quality of Recovery |
72; 93; 95 | — |
| SECONDARY Nausea |
4.3; 8.7; 12.5 | — |
| SECONDARY Pruritus |
8.7; 4.3; 4.1 | — |
Eligibility Criteria
Inclusion Criteria
- Healthy women (ASA 2)
- Between 18 and 45 years old
- Singleton term pregnancies
- Planned neuraxial anesthesia
Exclusion Criteria
- Refusal to participate
- Known allergy or contraindication to any medication used in the study
- Significant medical or obstetrical disease (ASA ≥ 3)
- Opioid use disorder
- Chronic pain syndrome
- Daily or near daily opioid use within last 3 weeks.
- Patient receiving a Monoamine oxidase inhibitors (MOAi)
Data sourced from ClinicalTrials.gov (NCT05069012) and the linked publication. Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.