Phase 3
Completed N=199
Low-Titer O Positive Whole Blood Versus Component Therapy for Emergent Transfusion in Trauma Patients
Hemorrhagic shock · Acute Blood Loss Anemia · Traumatic Brain Injury
Source: ClinicalTrials.gov NCT05081063 ↗
Enrolled (actual)
199
Serious AEs
0.0%
Results posted
Aug 2025
Primary outcomePrimary: Packed Red Blood Cells Equivalents Units Transfused (1 Whole Blood Unit Treated as 1 Packed Red Blood Cell Unit and 1 Fresh Frozen Plasma Unit) — 3.8; 5.7 units
◆ Published Evidence
Emerging
3citations · ~3 / year
Pragmatic O-Positive Whole-blood RandoMizaTion in male trauma Patients (POWeR-MTP).
Summary
Adult male patients brought to the emergency department as Level A trauma activations who are receiving emergency blood transfusion.
Objectives
1. Evaluate PRBC equivalents transfused in each group in the first 24 hours (Primary outcome)
2. Evaluate total transfusion in each group in the first 24 hours (Secondary Outcome) including breakdown by FFP equivalents, platelet units, and cryoprecipitate
3. Evaluate 6 hour, 24 hour, and hospital mortality (Secondary Outcome)
4. Evaluate ICU outcomes in each group
Linked Publications
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Pragmatic O-Positive Whole-blood RandoMizaTion in male trauma Patients (POWeR-MTP).
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Packed Red Blood Cells Equivalents Units Transfused (1 Whole Blood Unit Treated as 1 Packed Red Blood Cell Unit and 1 Fresh Frozen Plasma Unit) |
3.8; 5.7 | — |
| SECONDARY Mortality |
4; 13 | — |
Eligibility Criteria
Inclusion Criteria
- all adult male patients brought into the emergency department as LEVEL A trauma activations who are receiving emergency blood transfusions
Exclusion Criteria
- Female patients (specifically excluded due to risk of alloimmunization of Rh-negative female patients of childbearing age against Rh-positive blood)
- children
- prisoners
- all patients classified as dead upon arrival to the trauma bay
Data sourced from ClinicalTrials.gov (NCT05081063) and the linked publication. Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.