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Home › Conditions › Traumatic Brain Injury

Traumatic Brain Injury

Part of Brain Injury

26 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Traumatic Brain Injury

129 trials tracked for Traumatic Brain Injury: 14 in phase 3 or 4 and 8 with published results. The most-cited published study has 119 citations.

129Trials tracked
14Phase 3 & 4
0Recruiting
8With published results
Phase distribution
Phase 4 5 Phase 3 9 Phase 2 22 Phase 1 5 Other / NA 88
  1. Phase 3 Clinical Study to Investigate the Efficacy and Safety of Two Dose Levels of NT 201 Versus Placebo in Treating Chronic Troublesome Sialorrhea in Various Neurological Conditions Completed · 119 cited
  2. Phase 3 Clinical Study to Investigate the Efficacy and Safety of NT 201 Compared to Placebo in the Treatment of Chronic Troublesome Drooling Associated With Neurological Disorders and/or Intellectual Disability Completed · 40 cited
  3. Phase 4 Methylphenidate for Attention Problems After Pediatric TBI Completed · 22 cited
  4. Phase 3 Rivastigmine Patch in Veterans With Cognitive Impairment Following TBI Completed · 15 cited
  5. Phase 3 Brain and Gut Plasticity in Mild TBI or Post-acute COVID Syndrome Following Growth Hormone Therapy Completed · 6 cited
  6. Phase 3 Inhaled Nitric Oxide in Brain Injury Completed · 4 cited
Show 44 more trials
  1. Phase 3 Low-Titer O Positive Whole Blood Versus Component Therapy for Emergent Transfusion in Trauma Patients Completed · 3 cited
  2. Phase 4 Buspirone for the Treatment of Traumatic Brain Injury (TBI) Irritability and Aggression Completed
  3. Phase 4 Anterior Pituitary Hormone Replacement in Traumatic Brain Injury Completed
  4. Phase 4 Treatment of Traumatic Brain Injury (TBI)-Related Attention Deficits in Children Completed
  5. Phase 4 Assess Safety and Efficacy of Levetiracetam(LEV;Keppra)for Seizure Prevention Completed
  6. Phase 3 Effects of Erythropoietin on Cerebral Vascular Dysfunction and Anemia in Traumatic Brain Injury Completed
  7. Phase 3 Treatment Strategy to Prevent Mood Disorders Following Traumatic Brain Injury Completed
  8. Phase 3 Effectiveness of Amantadine Hydrochloride for Treatment of Severe Traumatic Brain Injury (TBI) Completed
  9. Phase 2 DASH After TBI Study: Decreasing Adrenergic or Sympathetic Hyperactivity After Traumatic Brain Injury Completed
  10. Phase 2 A Clinical Trial to Determine the Safety and Efficacy of Hope Biosciences Autologous Mesenchymal Stem Cell Therapy for the Treatment of Traumatic Brain Injury and Hypoxic-Ischemic Encephalopathy Completed
  11. Phase 2 Dopamine Receptor Imaging to Predict Response to Stimulant Therapy in Chronic TBI Completed
  12. Phase 2 Chronic Postconcussive Headache: A Placebo-Controlled Treatment Trial of Prazosin Completed
  13. Phase 2 Phase 2 a Study to Assess Safety and Pharmacokinetics of VAS203 in Patients With Traumatic Brain Injury Completed
  14. Phase 2 Prospective Analysis of the Use of N-Acetylcysteine and Vitamins in the Treatment of TBI in Geriatric Patients Completed
  15. Phase 2 Resuscitative Endocrinology:Single-dose Clinical Uses for Estrogen-Traumatic Brain Injury Completed
  16. Phase 2 Safety and Feasibility of Minocycline in the Treatment of Traumatic Brain Injury (TBI) Completed
  17. Phase 2 Brain Tissue Oxygen Monitoring in Traumatic Brain Injury (TBI) Completed
  18. Phase 2 Clinical Evaluation of Flortaucipir F 18 Completed
  19. Phase 2 Near Infrared Spectroscopy (NIRS) as Transfusion Indicator in Neurocritical Patients Completed
  20. Phase 2 Efficacy of Bromocriptine For Fever Reduction in Acute Neurologic Injury Completed
  21. Phase 2 Functional Connectivity as a Biomarker of rTMS Completed
  22. Phase 2 Ghrelin (OXE--103) for Acute Concussion Management Completed
  23. Phase 2 Prehospital Tranexamic Acid Use for Traumatic Brain Injury Completed
  24. Phase 2 A Study of Modified Stem Cells in Traumatic Brain Injury (TBI) Completed
  25. Phase 2 Recombinant Human Growth Hormone During Rehabilitation From Traumatic Brain Injury. Completed
  26. Phase 2 Hyperbaric Treatment of Traumatic Brain Injury (TBI) Completed
  27. Phase 2 Cold-stored Platelet Early Intervention in TBI Completed
  28. Phase 2 Hyperbaric Oxygen Therapy (HBO2) for Persistent Post-concussive Symptoms After Mild Traumatic Brain Injury (mTBI) Completed
  29. Phase 2 Allopregnanolone for the Treatment of Traumatic Brain Injury Completed
  30. Phase 2 Sleep Management And Recovery After Traumatic Brain Injury in Kids: Pilot Intervention of Melatonin Completed
  31. Phase 1 Behavioral and Neuroimaging Changes After Cognitive Rehab in Traumatic Brain Injuries (TBI) and Mild Cognitive Impairment (MCI) Completed
  32. Phase 1 DHA For The Treatment of Pediatric Concussion Related to Sports Injury Completed
  33. Phase 1 Delayed Versus Early Enoxaparin Prophylaxis After Traumatic Brain Injury (TBI) Completed
  34. Phase 1 Remediation of Impaired Self-Regulation in Patients With Mild TBI Completed
  35. Phase 1 Biological Signatures, Probiotic Among Those With mTBI and PTSD Completed
  36. N/A Traditional Balance vs Vibrotactile Feedback Training for Vestibular Rehabilitation Completed
  37. N/A Test of Chamber Pressure to Divers and Chamber Attendants Completed
  38. N/A Intervention to Change Attributions That Are Negative (ICAN) Completed
  39. N/A High-Definition Transcranial Direct Current Stimulation (HD-tDCS) for Sensory Deficits in Complex Traumatic Brain Injury Completed
  40. N/A Pilot and Feasibility of MEMI for Chronic Traumatic Brain Injury Completed
  41. N/A Can Early Initiation of Rehabilitation With Wearable Sensor Technology Improve Outcomes in mTBI? Completed
  42. N/A Cognitively Augmented Behavioral Activation for Veterans With Comorbid TBI/PTSD Completed
  43. N/A Approaches to Auditory Rehabilitation for Mild Traumatic Brain Injury Completed
  44. N/A Shock, Whole Blood, and Assessment of TBI S.W.A.T. (LITES TO 2) Completed

Showing the 50 most-cited and recently-updated of 129 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Tranexamic acid reduces mortality in TBI patients with high brain voxel percentages
Radiology & Imaging RCT
Tranexamic acid reduces mortality in TBI patients with high brain voxel percentages Trial shows brain imaging helps identify patients who benefit from TXA
This post hoc analysis of an RCT involving 550 patients with moderate or severe traumatic brain injury (TBI) evaluated the impact of tranexa…
A new analysis suggests that specific brain scans can help doctors identify which traumatic brain injury patients might benefit most from a …
Jun 9, 2026
Arterial hypotension is a late sign of decompensated shock linked to increased mortality and adverse neurologic outcomes in critically ill children
Pediatrics Guideline
Arterial hypotension is a late sign of decompensated shock linked to increased mortality and adverse neurologic outcomes in critically ill children Low blood pressure in sick kids signals danger and needs careful management
This guideline narrative review addresses arterial hypotension, septic shock, and traumatic brain injury in critically ill infants and child…
Low blood pressure in critically ill children often means shock is worsening. Experts now suggest aiming for targets at least at the 10th pe…
Frontiers Jun 2, 2026
NINJ1 targeting shows potential for multiple sclerosis and other neurological conditions but faces significant knowledge gaps
Hematology Sys. Review
NINJ1 targeting shows potential for multiple sclerosis and other neurological conditions but faces significant knowledge gaps NINJ1 targeting shows promise for multiple sclerosis and other brain injuries
This narrative review examines NINJ1 targeting as a therapeutic strategy for multiple sclerosis, ischemic stroke, traumatic brain injury, sp…
A review suggests NINJ1 targeting could help treat multiple sclerosis, stroke, and other brain injuries, though more research is needed.
Frontiers May 30, 2026
Narrative review suggests music therapy may improve cognition and neuropsychiatric symptoms in cognitive impairment
Neurology Sys. Review
Narrative review suggests music therapy may improve cognition and neuropsychiatric symptoms in cognitive impairment Music therapy may help minds affected by Alzheimer's and other cognitive conditions
This narrative review examines the role of music therapy for cognitive impairment. The authors suggest that music therapy may improve cognit…
Music therapy might improve thinking and mood for people with Alzheimer's disease, mild cognitive impairment, or Parkinson's-related cogniti…
Frontiers May 28, 2026
Systematic review on EEG monitoring versus ICP in traumatic brain injury patients
Neurology Meta-analysis
Systematic review on EEG monitoring versus ICP in traumatic brain injury patients Doctors found a link between brain wave monitors and pressure in injured patients inside the ICU
This systematic review examined the relationship between electroencephalography (EEG) monitoring and intracranial pressure (ICP) in adult pa…
A review of studies shows brain wave monitoring might help track pressure in injured adults. More research is needed to prove these tools wo…
Frontiers May 26, 2026
Protocol for a review on neurosurgical intervention versus conservative management in older adults with traumatic brain injury
Neurology Meta-analysis
Protocol for a review on neurosurgical intervention versus conservative management in older adults with traumatic brain injury This plan guides surgery choices for older adults with brain injuries to improve care
This is a protocol for a planned review on traumatic brain injury in adults aged 65 years and older. It will compare neurosurgical intervent…
This document outlines a plan to study surgery for older adults with brain injuries. It will compare surgical treatment against non-surgical…
Frontiers May 19, 2026
Case report review suggests LAI paliperidone stabilizes behavior in a 9-year-old with TBI over two years
Psychiatry Sys. Review
Case report review suggests LAI paliperidone stabilizes behavior in a 9-year-old with TBI over two years Long-acting shots help a boy control severe brain injury rage
This case report review describes a 9-year-old boy with severe traumatic brain injury and posttraumatic confusional state treated with long-…
A boy with severe brain injury rage found calm after months of failed pills, showing long-acting shots could help when daily medicine fails
Frontiers Apr 29, 2026
AutoML-based model predicts blood transfusion needs in severe traumatic brain injury patients with high accuracy
Neurology Cohort
AutoML-based model predicts blood transfusion needs in severe traumatic brain injury patients with high accuracy AI Model Predicts Blood Transfusion Needs in Severe Brain Injury
This retrospective cohort study evaluated an AutoML-based interpretable prediction model in 638 patients with severe traumatic brain injury …
An AI tool accurately predicts which severe brain injury patients need blood transfusions, potentially saving time and resources.
Frontiers Apr 29, 2026
Machine learning model predicts functional status in patients with traumatic brain injury, intracerebral hemorrhage, or aneurysmal subarachnoid hemorrhage
Neurology Cohort
Machine learning model predicts functional status in patients with traumatic brain injury, intracerebral hemorrhage, or aneurysmal subarachnoid hemorrhage New tool uses liver blood work to predict brain injury
This retrospective cohort study developed a machine learning model using liver function markers and other features to predict functional sta…
A new computer model uses liver blood tests to predict how well brain injury patients will recover after surgery.
Frontiers Apr 29, 2026
Serum 25(OH)D, AQP4, and IL-4 levels tracked after traumatic brain injury
Rheumatology Cohort
Serum 25(OH)D, AQP4, and IL-4 levels tracked after traumatic brain injury Low Vitamin D Linked to Worse Brain Swelling After Injury
This observational cohort study of 279 patients with traumatic brain injury measured serum biomarkers over 7 days.
It starts with a fall, a crash, or a blow to the head.
Frontiers Apr 23, 2026
Machine learning model for mortality prediction in ICU traumatic brain injury patients
Neurology Cohort
Machine learning model for mortality prediction in ICU traumatic brain injury patients New AI Model Predicts Brain Injury Death Risk Better
This observational cohort study from the MIMIC-IV database developed an interpretable machine learning model to predict in-hospital mortalit…
A new computer tool helps doctors understand survival chances for brain injury patients more clearly.
Frontiers Apr 23, 2026
Independent skills practice between music therapy sessions linked to fewer symptoms in TBI/PTSD patients
Neurology RCT
Independent skills practice between music therapy sessions linked to fewer symptoms in TBI/PTSD patients Music Homework Between Sessions Helps Veterans Recover Better
This retrospective observational analysis of military-connected individuals with traumatic brain injury and/or post-traumatic stress disorde…
Simple music exercises at home may help veterans feel better between therapy visits.
Frontiers Apr 22, 2026

Research across Brain Injury

Related studies from across the Brain Injury family.

High-altitude ICU study finds 21% AKI incidence in neurocritical patients
Nephrology Cohort
High-altitude ICU study finds 21% AKI incidence in neurocritical patients High-altitude ICU patients face kidney injury risk
This retrospective cohort study of 390 adult neurocritical patients at a high-altitude ICU found that 83 patients (21.3%) developed acute ki…
A study of 390 adults in a high-altitude ICU found that 1 in 5 developed acute kidney injury, linked to older age and higher hemoglobin leve…
Frontiers Apr 24, 2026
Short-course beta-lactam prophylaxis reduces early-onset VAP in mechanically ventilated patients with acute brain injury
Infectious Disease Meta-analysis
Short-course beta-lactam prophylaxis reduces early-onset VAP in mechanically ventilated patients with acute brain injury Short Antibiotics Cut Early Lung Infections in Brain Injury Patients
This systematic review and meta-analysis evaluated short-course systemic beta-lactam antibiotic prophylaxis versus control in 1,673 mechanic…
Short antibiotic courses cut early lung infections in brain injury patients on ventilators, reducing hospital stays without increasing death…
Apr 14, 2026
Cross-sectional survey examines concussion diagnosis prevalence in US children and adolescents
Neurology
Cross-sectional survey examines concussion diagnosis prevalence in US children and adolescents How many U.S. kids have been diagnosed with a concussion or brain injury?
A cross-sectional survey using National Health Interview Survey data examined the percentage of US children and adolescents aged ≤17 years w…
A national survey is waiting to reveal how many U.S. children and teens have ever received a diagnosis for a concussion or brain injury.
CDC Apr 3, 2026
Review suggests TWEAK-Fn14 axis contributes to brain injury and cardiac dysfunction pathology
Cardiology Sys. Review
Review suggests TWEAK-Fn14 axis contributes to brain injury and cardiac dysfunction pathology Review explores protein link between brain and heart diseases
A systematic review summarizes evidence on the TWEAK-Fn14 signaling pathway in cardio-cerebrovascular diseases.
High levels of two specific proteins linked to brain swelling and heart scarring may offer a future target for treating brain-heart syndrome…
Frontiers Apr 2, 2026

Questions about Traumatic Brain Injury

Can a non-invasive vagus nerve stimulation treatment help adults with chronic mild traumatic brain injury and PTSD?

Early evidence suggests non-invasive vagus nerve stimulation may reduce symptoms in adults with chronic mild TBI and PTSD, but more research is needed.

Full answer →
Can a machine learning model predict hospital death for ICU patients with traumatic brain injury?

Yes, machine learning models can predict hospital death for ICU patients with traumatic brain injury, with studies reporting over 80% accuracy.

Full answer →
How well does a machine learning model predict functional status after traumatic brain injury?

Machine learning models, particularly CatBoost, can predict functional outcomes after TBI with high accuracy (AUC up to 0.94), but most models need more external validation before routine clinical use.

Full answer →

All Traumatic Brain Injury Articles