N/A
Completed N=382
A Gender Transformative Implementation Strategy With Providers to Improve HIV Outcomes in Uganda
Source: ClinicalTrials.gov NCT05178979 ↗Enrolled (actual)
382
Serious AEs
0.3%
Results posted
Apr 2025
Primary outcomePrimary: Change in Proportion of Missed Antiretroviral (ARV) Doses From Baseline Among Clients — 90.14; 91.68; 95.64; 96.73 percentage of total missed ARV doses — p=0.38
Summary
Gender norms embedded in the health-system and broader community shape patient-provider relationships in ways that may undermine the provision of antiretroviral treatment (ART) counseling for men and women in Uganda. This study seeks to develop and evaluate the acceptability, feasibility, and preliminary efficacy of an innovative gender transformative implementation strategy to improve HIV provider capacity for equitable HIV care and ART adherence counseling.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Change in Proportion of Missed Antiretroviral (ARV) Doses From Baseline Among Clients |
90.14; 91.68; 95.64; 96.73; 95.45; 100.00 | 0.38 |
| PRIMARY Change in Clinic Visit Adherence From Baseline Among Patients (Retention in Care) |
0.96; 0.95; 0.99; 0.98; 0.99; 1.00 | 0.37 |
| PRIMARY Change in Competence for Gender-sensitive Care From Baseline Among Providers |
3.78; 3.55; 3.95; 3.48; 3.82; 3.61 | 0.004 sig |
| SECONDARY Change in Self-efficacy for Client-centered Communication From Baseline Among Providers |
3.08; 3.15; 3.24; 3.26; 2.98; 3.28 | <0.001 sig |
| SECONDARY Change in Empathy Towards Clients From Baseline Among Providers |
3.77; 3.62; 3.86; 3.54; 3.91; 3.63 | <0.001 sig |
| SECONDARY Change in the Use of Emotional Regulation and Stress Reduction Techniques From Baseline Among Providers |
1.64; 1.99; 1.93; 1.86; 2.03; 2.06 | 0.01 sig |
| SECONDARY Change in Perceived Quality of Communication From HIV Providers From Baseline Among Clients |
2.33; 2.25; 2.53; 2.32; 2.14; 2.88 | <0.001 sig |
| SECONDARY Change in Perceived Level of Participatory Decision-making Related to HIV Care From Baseline Among Clients |
1.86; 2.19; 2.11; 2.69; 2.52; 2.75 | <0.001 sig |
| SECONDARY Change in Satisfaction With HIV Care From Baseline Among Clients |
3.38; 3.26; 3.29; 3.19; 3.09; 3.27 | <0.001 sig |
| SECONDARY Change in Total HIV Stigma Score Among Clients |
0.60; 0.60; 0.59; 0.58; 0.45; 0.71 | 0.01 sig |
| SECONDARY Change in Anticipated HIV Stigma Among Clients |
0.79; 0.67; 0.80; 0.57; 0.59; 0.90 | <0.001 sig |
| SECONDARY Change in Enacted HIV Stigma Among Clients |
0.21; 0.14; 0.16; 0.14; 0.12; 0.17 | 0.004 sig |
| SECONDARY Change in Internalized HIV Stigma Among Clients |
0.78; 0.99; 0.82; 1.01; 0.62; 1.04 | 0.24 |
Eligibility Criteria
Provider Cohort:
Inclusion Criteria
- HIV care provider at the selected clinics, including HIV medical and clinical officers, nurses, midwives, linkage facilitators, counselors.
- 18 years of age or older
- Fluent in English or Luganda
Patient Cohort:
Inclusion Criteria
- HIV-infected
- Enrolled in care at the clinic of recruitment
- pre-ART (newly diagnosed) or newly initiated on ART (within 3 months-1 year) or struggling with treatment adherence, defined in two ways: (1) most recent viral load results unsuppressed as assessed through clinic records; (2) or self-reported non-adherence as by the Adult AIDS Clinical Trials Group (AACTG) scale 4-day adherence recall questions. This scale has demonstrated good construct validity in Uganda and strong correlations with viral load;
- 18 years of age or an emancipated minor
- Fluent in Luganda or English
Data sourced from ClinicalTrials.gov (NCT05178979). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.