Early Phase 1
N=10
Influence of Edible Marijuana on Endurance Exercise Performance
Endurance Exercise
Bottom Line
View on ClinicalTrials.gov: NCT05192239 ↗Enrolled (actual)
10
Serious AEs
0.0%
Results posted
Apr 2024
Primary outcome: Primary: Comparison of Blood Lactate Levels During a 24 Minute Graded Standard Exercise Test (50 Watts, 100 Watts, and 150 Watts) to Placebo. — 0.9699; 1.1437; 1.26345; 1.3618 mmol/L
Study Design & Population
- Study type
- Interventional
- Phase
- Early Phase 1
- Interventions
- THC 5 (Drug); Placebo (Drug)
- Age
- Adult · 21+ yrs
- Sex
- All
- Sponsor
- Christopher Bell
- Primary completion
- Jul 2022
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Comparison of Blood Lactate Levels During a 24 Minute Graded Standard Exercise Test (50 Watts, 100 Watts, and 150 Watts) to Placebo. |
0.9699; 1.1437; 1.26345; 1.3618; 1.6075; 1.3558333 | — |
| PRIMARY Comparison of Heart Rate During a 24 Minute Graded Standard Exercise Test (50 Watts, 100 Watts, and 150 Watts) to Placebo. |
66; 63; 95; 97; 108; 113 | — |
| PRIMARY Comparison of Rating of Perceived Exertion (RPE) During a 24 Minute Graded Standard Exercise Test (50 Watts, 100 Watts, and 150 Watts) to Placebo. |
6; 6; 8; 8; 11; 10 | — |
| PRIMARY Comparison of Indirect Calorimetry (VO2) During a 24 Minute Graded Standard Exercise Test (50 Watts, 100 Watts, and 150 Watts) to Placebo. |
1.26404; 1.24939816; 1.66361; 1.664867728; 2.11388; 2.126941406 | — |
| PRIMARY Comparison of Maximal Mean Power Output to Placebo |
422; 454 | — |
| PRIMARY Comparison of Time to Exhaustion to Placebo |
43; 43 | — |
Summary
Lots of people, including athletes and people who like to exercise regularly, enjoy marijuana. Some people believe marijuana might improve their ability to exercise. There are no recent, up-to-date scientific studies to suggest that this belief is right or wrong. The goal of this study is to determine the influence of marijuana on exercise performance.
Eligibility Criteria
Inclusion Criteria
- Between the age of 21 and 40.
- Weigh more than 110 pounds
- Habitual user of cannabis; average use of THC minimum of once per month during the previous year
- Prior use of cannabis product containing at least 10 mg of THC with no adverse reaction
- Habitual exerciser: exercised a minimum of 5 days per week, for a minimum of 30-minutes/session, during the previous year.
Exclusion Criteria
- Identification of a contra-indication to exercise during a 12-lead exercise stress test.
- Pregnant or trying to become pregnant. Breastfeeding.
- Recipient of treatment for psychotic or bipolar disorder during the previous 2 years
- Recipient of treatment for Schizophrenia during the previous 2 years
- Planned surgery scheduled within 2-weeks of study participation
Data sourced from ClinicalTrials.gov (NCT05192239). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.