Early Phase 1
Completed N=10
Influence of Edible Marijuana on Endurance Exercise Performance
Source: ClinicalTrials.gov NCT05192239 ↗Enrolled (actual)
10
Serious AEs
0.0%
Results posted
Apr 2024
Primary outcomePrimary: Comparison of Blood Lactate Levels During a 24 Minute Graded Standard Exercise Test (50 Watts, 100 Watts, and 150 Watts) to Placebo. — 0.9699; 1.1437; 1.26345; 1.3618 mmol/L
Summary
Lots of people, including athletes and people who like to exercise regularly, enjoy marijuana. Some people believe marijuana might improve their ability to exercise. There are no recent, up-to-date scientific studies to suggest that this belief is right or wrong. The goal of this study is to determine the influence of marijuana on exercise performance.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Comparison of Blood Lactate Levels During a 24 Minute Graded Standard Exercise Test (50 Watts, 100 Watts, and 150 Watts) to Placebo. |
0.9699; 1.1437; 1.26345; 1.3618; 1.6075; 1.3558333 | — |
| PRIMARY Comparison of Heart Rate During a 24 Minute Graded Standard Exercise Test (50 Watts, 100 Watts, and 150 Watts) to Placebo. |
66; 63; 95; 97; 108; 113 | — |
| PRIMARY Comparison of Rating of Perceived Exertion (RPE) During a 24 Minute Graded Standard Exercise Test (50 Watts, 100 Watts, and 150 Watts) to Placebo. |
6; 6; 8; 8; 11; 10 | — |
| PRIMARY Comparison of Indirect Calorimetry (VO2) During a 24 Minute Graded Standard Exercise Test (50 Watts, 100 Watts, and 150 Watts) to Placebo. |
1.26404; 1.24939816; 1.66361; 1.664867728; 2.11388; 2.126941406 | — |
| PRIMARY Comparison of Maximal Mean Power Output to Placebo |
422; 454 | — |
| PRIMARY Comparison of Time to Exhaustion to Placebo |
43; 43 | — |
Eligibility Criteria
Inclusion Criteria
- Between the age of 21 and 40.
- Weigh more than 110 pounds
- Habitual user of cannabis; average use of THC minimum of once per month during the previous year
- Prior use of cannabis product containing at least 10 mg of THC with no adverse reaction
- Habitual exerciser: exercised a minimum of 5 days per week, for a minimum of 30-minutes/session, during the previous year.
Exclusion Criteria
- Identification of a contra-indication to exercise during a 12-lead exercise stress test.
- Pregnant or trying to become pregnant. Breastfeeding.
- Recipient of treatment for psychotic or bipolar disorder during the previous 2 years
- Recipient of treatment for Schizophrenia during the previous 2 years
- Planned surgery scheduled within 2-weeks of study participation
Data sourced from ClinicalTrials.gov (NCT05192239). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.