N/A
N=33
Role of the Protein Matrix in the Anabolic Response to a Ground Beef Patty as Opposed to the Impossible (Vegi-) Burger
Protein Metabolism
Bottom Line
View on ClinicalTrials.gov: NCT05197140 ↗Enrolled (actual)
33
Serious AEs
0.0%
Results posted
Aug 2024
Primary outcome: Primary: Postprandial Plasma Essential Amino Acid Concentration Incremental Area-under-the-curve [ Time Frame: 360 Minutes] — 117896; 75098; 94058 micromoles per liter per minute
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- food: cooked 85% lean ground beef (Other); food: Impossible Burger (R) (Other)
- Age
- Adult · 18+ yrs
- Sex
- All
- Sponsor
- University of Arkansas
- Primary completion
- Nov 2022
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Postprandial Plasma Essential Amino Acid Concentration Incremental Area-under-the-curve [ Time Frame: 360 Minutes] |
117896; 75098; 94058 | — |
Summary
Several of the investigator's recent studies have shown that all dietary proteins are not equal when it comes to making proteins in human bodies. Generally, foods made from animal muscle tissue are much more efficient at making new proteins in the body that those from plant sources. This study will measure the amount of protein growth in participants after consuming either one beef patty, one vegi-burger, or two vegi-burgers. By using stable isotope infusions and collecting blood and leg muscle samples, the investigator's lab can determine the rate of muscle metabolism that happens after a participant eats a protein-containing food. The investigator wants to determine if the vegi-burger is as efficient as the beef patty at creating proteins in a participants. The investigator will measure this metabolism over a 10-hour period, with the food being eaten at the 4 hour mark. The investigator plans to perform this procedure on up to 8 participants per food option (24 total).
Eligibility Criteria
Inclusion Criteria
- Ages 18 - 40 yrs.
- Body Mass Index of 20-32 inclusive
Exclusion Criteria
- Unwilling to eat animal proteins
- History of diabetes that requires medication for control of blood glucose
- History of malignancy or chemo/radiation therapy in the 6 months prior to enrollment
- History of gastrointestinal bypass/reduction surgery (Lapband, gastric sleeve, etc.)
- Pregnant females
- Hemoglobin less than 12 g/dL at screening
- Platelets less than 150,000 at screening
- Subjects who cannot refrain from using protein or amino acid supplements for 7 days prior to Visit 3
- Concomitant use of oral or injectable corticosteroids
- Concomitant use of testosterone, IGF-1, or similar anabolic agent
- Any other disease or condition that would place the subject at increased risk of harm if they were to participate, at the discretion of the study physician
Data sourced from ClinicalTrials.gov (NCT05197140). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.