N/A N=15 Effect of Caloric Restriction and Protein Intake on Metabolism and Anabolic Sensitivity
Weight Loss · Starvation
Primary: Change in Resting Metabolic Rate — -63.4; -77.6; -47.4 kcal change
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=24 Metabolic Effect of High-protein Meals in Men
Healthy
Primary: Post-prandial Plasma Responses of Glucose Concentrations — 136.5; 121.2; 102.9; 160.3 mmole/L*min
Phase 2 N=13 High Protein Diet in Patients With Long-chain Fatty Acid Oxidation Disorders
Very Long-chain Acyl-CoA Dehydrogenase Deficiency · Trifunctional Protein Deficiency · Carnitine Palmitoyltransferase 2 Deficiency
Primary: Energy Expenditure — 2045; 2343 kcal
N/A N=8 Whole Body Protein Metabolism of a Whey/EAA Supplement Using Continuous Oral Stable Isotopes
Healthy
Primary: Whole-body Protein Net Balance — 6.2; 11.8 grams
N/A N=16 Effect of an EAA/Whey Composition on Protein Metabolism
Sarcopenia
Primary: Protein Anabolism — 3.56; 11.8; 3.02 grams — p=<0.05
Phase 2 N=56 Milk Protein Feeding After Aerobic Exercise in Older Adults With Pre-diabetes Taking the Biguanide Metformin
Physical Activity
Primary: Mitochondrial Function — 7.1; 43.2; 15.6; 13.8 percent change in pmol/s/mg tissue
N/A N=39 The Effect of Protein-enriched Diet on Body Composition and Appetite
Overweight · Obese · Metabolic Syndrome
Primary: Change in Lipid Content of the Liver (Intrahepatocellular Lipid) — 27.9; 9.3; 21.4; 5.9 % IHCL — p=<0.05
N/A N=20 Essential Amino Acids and Protein Kinetics During Caloric Deprivation
Muscle Protein Synthesis · Whole-body Protein Balance
Primary: Postprandial, Resting Muscle Protein Synthesis Rates — 0.055; 0.061 percent per hour
N/A N=33 Role of the Protein Matrix in the Anabolic Response to a Ground Beef Patty as Opposed to the Impossible (Vegi-) Burger
Protein Metabolism
Primary: Postprandial Plasma Essential Amino Acid Concentration Incremental Area-under-the-curve [ Time Frame: 360 Minutes] — 117896; 75098; 94058 micromoles per liter per minute
N/A N=96 Effect of High Protein Weight Loss for Seniors
Obesity · Weight Loss
Primary: Change in 400 Meter Gait Walk Speed — 0.01; -0.02 meters/second
N/A N=87 Modulation of the Intestinal Microbiome by a High Protein Diet
Obesity
Primary: Weight Loss (% Change) in Response to Dietary Intervention Change — -3.83; -3.89 percentage weight change from baseline
N/A N=44 Maximizing the Dietary Pattern of Older Adults: the Effects of Protein Intake on Protein Kinetics
Sarcopenia
Primary: Whole Body Protein Turnover — -0.16; -0.17; 0.48 g/kg lean body mass/day
Phase 1 N=62 Muscle Perfusion and Protein Metabolism in Elderly
Aging
Primary: Mixed Muscle Fractional Synthesis Rate (FSR) — 0.061; 0.070; 0.066; 0.070 Fractional Synthesis Rate (pecent/hour)
N/A N=187 Utilizing Protein During Weight Loss to Impact Physical Function
Obesity · Weight Loss · Diet Modification
Primary: Change in Expanded Short Physical Performance Battery Score — 0.06; 0.11; 0.16 score on a scale — p=0.16
N/A N=37 Forearm Immobilization, Metabolic Health, and Muscle Loss
Healthy
Primary: Percent Change in Forearm Glucose Uptake — -73; 127; -95 Percent change in clamp FGU with immob
Phase 3 N=500 Supplemental Enteral Protein in Critical Illness
Nutrition Disorder · Trauma · Critical Illness
Primary: Serum Concentrations of Transthyretin at 3 Weeks After Injury. — 18.1; 18.9 mg/dl
Phase 4 N=20 Absorption Comparison on Equivalency Value of Genepro Gen2
Analysis, Event History · Absorption; Disorder, Protein
Primary: Weekly Blood Draws to Measure Blood Protein Levels — 7.23; 6.86; 7.43; 7.21 grams per deciliter
N/A N=141 Impact of Protein and Alkali Supplementation on Skeletal Muscle in Older Adults
Age-Related Sarcopenia · Muscle Loss
Primary: Double Leg Press Peak Power at 70% — 260.3; 255.6; 251.1; 264.8 Watts
N/A N=64 Veterans Achieving Weight Loss and Optimizing Resilience-Using Protein
Prediabetes · Obesity
Primary: Total Short Physical Performance Battery (SPPB) Score at Baseline — 9.5; 9.6 score on a scale
N/A N=13 (KIWI) Speeding up a Slow Protein for Muscle Mass With Hay Kiwifruit
Metabolism · Protein
Primary: Whole Body Net Balance Measured by Gas Chromatography-Mass Spectrometry (GC-MS) — 14.58; 14.55 g protein per 300 mins
N/A N=27 "Ounce-equivalents" in the Protein Foods Group: Benefits of Quality
Protein Metabolism
Primary: Net Protein Synthesis Rate — 8.65; 1.97; 5.69 grams — p=<0.05
Phase 3 N=92 Optimizing Protein Intake in Older Americans With Mobility Limitations
Mobility Limitation
Primary: Change in Lean Body Mass as Measured by Dual Energy X-ray Absorptiometry (DXA) — 0.14; 0.74; 4.43; 4.13 kg
N/A N=187 Utilizing Protein During Weight Loss to Impact Physical Function and Bone
Obesity · Weight Loss · Diet Modification
Primary: 18-month Change From Baseline in Total Hip Trabecular Volumetric Bone Mineral Density Assessed by Computed Tomography (CT) in mg/cm^3 — -0.91; -1.77; -0.03 mg/cm^3…
N/A N=105 Protein Supplementation in Elderly With Sarcopenic Obesity Undergoing Caloric Restriction and Exercise
Sarcopenic Obesity · Aging
Primary: Percentage of Fat-free Mass — 49.6; 50.3; 50.5; 52.5 percentage of fat-free mass — p=0.013
N/A N=12 Inflammation and Protein Restriction
Protein Restriction · Diet · Inflammation
Primary: Changes in the Human Intestinal Microbiome That Result From Short Term Dietary Adjustment. — 232; 172; 145; 93 Number of immunity related genes — p=0.05
Phase 2 N=22 Hydroxyproline Influence on Oxalate Metabolism
Hyperoxaluria
Primary: Mean Percent Conversion of Hydroxyproline (Hyp) to Urinary Oxalate (UOx) — 12.8; 32.9; 14.8 percent converted
N/A N=22 Regulation of Muscle Protein Phenotype in Humans With Obesity
Obesity
Primary: Whole-Muscle Protein Synthesis — 0.004; 0.015 %/hr
Phase 4 N=12 The Effect of Protein on Calcium Absorption and Gastric Acid Production
Osteoporosis
Primary: Percent Change in Intestinal Calcium Absorption — 34.2; 31.5 percentage of calcium absorption
Phase 2 N=208 The Effect of Protein Supplementation on Bone Health in Healthy Older Men and Women
Bone Resorption · Osteoporosis
Primary: Change in Anterior-posterior Spine Bone Mass Density Measured by Dual Energy X-ray Absorptiometry (DXA) Compared to Baseline — 0.51; 0.51 percentage change
N/A N=12 Optimizing Protein Patterns for Skeletal Muscle Preservation and Sleep in the Medical Management of Parkinson Disease
Parkinson Disease
Primary: Change in Markers of Skeletal Muscle Metabolism GDF15