N/A
N=34
Microelectrodes in Epilepsy
Epilepsy
Bottom Line
View on ClinicalTrials.gov: NCT05200455 ↗Enrolled (actual)
34
Serious AEs
6.7%
Results posted
Sep 2022
Primary outcome: Primary: Feasibility of Microelectrode Technology to Isolate Place Responsive Neurons in the Human Hippocampus as Measured by the Number of Place Responsive Neurons. — 79 place responsive neurons
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Microelectrodes (Device)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- Dartmouth-Hitchcock Medical Center
- Primary completion
- Mar 2021
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Feasibility of Microelectrode Technology to Isolate Place Responsive Neurons in the Human Hippocampus as Measured by the Number of Place Responsive Neurons. |
79 | — |
| SECONDARY How Precise the Frequencies (Alpha, Beta, Delta, Theta, Gamma, and High-gamma) of Neural Brain Activity Predict the Speed of the Participant at Performing the Cognitive Task (Accuracy Measured in Percentage). |
0.477; 0.490; 0.440; 0.444; 0.362; 0.382 | — |
Summary
The purpose of this study is to test microelectrodes in intracranial monitoring to see if they will provide novel information on the epileptic potential of the implanted brain tissue. A secondary objective is to investigate the activity of single neurons during specific cognitive tasks.
Eligibility Criteria
Inclusion Criteria
- 18-65 year old
- male or female
- right or left handed
- IQ>70
- medically refractory focal epilepsy requiring intracranial EEG for pre-surgical evaluation deemed medically necessary
- no contraindications to intracranial electrode study
- able and willing to participate in research
Exclusion Criteria
- does not meet the inclusion criteria
Data sourced from ClinicalTrials.gov (NCT05200455). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.