N/A
N=46
The Water Drinking Test in Glaucoma Study
Glaucoma
Bottom Line
View on ClinicalTrials.gov: NCT05283031 ↗Enrolled (actual)
46
Serious AEs
0.0%
Results posted
Sep 2024
Primary outcome: Primary: Maximum Intraocular Pressure Difference (Between mDCT and WDT) — -0.82 mmHg
Study Design & Population
- Study type
- Observational
- Phase
- N/A
- Interventions
- Modified Diurnal Tension Curve (Diagnostic_test)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- Imperial College London
- Primary completion
- Jun 2021
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Maximum Intraocular Pressure Difference (Between mDCT and WDT) |
-0.82 | — |
Summary
To investigate the correlation and agreement between the intraocular pressure peaks detected during the water drinking test and modified diurnal tension curve in glaucomatous eyes and to analyse whether this is associated with prognostic outcome. The study will also measure autonomic nervous system activation during the test to investigate one possible mechanism behind it.
Eligibility Criteria
Inclusion Criteria
- Able to give informed consent to participate in the study
- Aged between 18 and 80 years of age
- Clear optical media
- Spherical equivalent +-10 Dioptres
- Normal tension glaucoma proven by visual field testing or OCT imaging combined with clinical assessment.
- Primary open angle glaucoma proven by visual field testing or OCT imaging combined with clinical assessment.
Exclusion Criteria
- Are using ocular hypotensive therapy, or have done so in the last 30 days
- Have any other known ocular disease (except glaucoma)
- Have serious cardiac or kidney disease (WDT contra-indication)
- Have swallowing difficulties associated with either a neurological or gastrointestinal condition.
- Patients with any contra-indication of drinking large amounts of water in a small period of time e.g. swallowing impairment, oesophageal stricture, gastric banding.
- Have secondary or narrow/closed angle glaucoma
- Patients submitted to any surgical procedure or laser intervention during the evaluation period
Data sourced from ClinicalTrials.gov (NCT05283031). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.