N/A
Completed N=4
Accelerated Transcranial Magnetic Stimulation (TMS) for Smoking Cessation in People Living With HIV/AIDS (PLWHA)
HIV · Tobacco Smoking
Source: ClinicalTrials.gov NCT05295953 ↗
Enrolled (actual)
4
Serious AEs
0.0%
Results posted
Oct 2025
Primary outcomePrimary: Gaze Fixation on Smoking Cues — 320.19; 152.60 milliseconds
Summary
To demonstrate whether four sessions of TBS improves attentional bias and craving in PLWHA smokers compared to four sessions of sham stimulation. We hypothesize 4 sessions of TBS to the left DLPFC will significantly improve attentional bias and craving for smoking cues compared to neutral cues in a population of subjects who are smokers with HIV/AIDS compared to sham stimulation.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Gaze Fixation on Smoking Cues |
221.75; 120.50 | — |
| PRIMARY Craving for Cigarettes |
51; 28 | — |
| SECONDARY Number of Participants Showing Functional Connectivity Changes |
2; 1 | — |
Eligibility Criteria
Inclusion Criteria: Potential participants will be
- Patients enrolled in the Bluegrass Clinic
- 18-60 years of age
- Male or female gender
- Able to read, understand and communicate in English
- Willing to adhere to the general rules of the Bluegrass Clinic/SMARTClinic/Beyond Birth Clinic
- Willing and able to abstain from drug use other than Suboxone
- Exhaled breath on day of study carbon monoxide (CO) < 5 ppm
- Stabilized on maintenance buprenorphine if having comorbid opioid use disorder.
Exclusion Criteria
- Positive pregnancy test for females, traumatic brain injury, history of seizure disorder, history of or current diagnosis of schizophrenia, intracranial metal shrapnel.
- Previous adverse effect with TMS.
- Sub-threshold consistency while performing behavioral tasks.
- Failure to show baseline attentional bias to smoking versus neutral cues.
Data sourced from ClinicalTrials.gov (NCT05295953). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.