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N/A Completed N=43 Randomized Double-blind Prevention

Do Terpenes Play a Role in the Stress-reducing Effects of a Forest Bathing Intervention?

Monoterpene Exposure During a Forest Bathing Intervention
Source: ClinicalTrials.gov NCT05316597 ↗
Enrolled (actual)
43
Serious AEs
0.0%
Results posted
Sep 2024
Primary outcomePrimary: Changes in the HF (ms^2) Component of HRV — 6.65; 6.48 ms^2 — p=0.914

Summary

This pilot study evaluates the role terpenes play in the stress-reducing effects of a forest bathing intervention. Participants will participate in two interventions in random order: 1) terpene exposure and 2) no terpene exposure.

Outcome Measures

OutcomeResultp-value
PRIMARY
Changes in the HF (ms^2) Component of HRV
6.65; 6.48 0.914
PRIMARY
Baseline HF (ms^2) Component of HRV
6.48; 6.34
SECONDARY
Blood Pressure (Diastolic in mmHg)
75.4; 73.2 .554
SECONDARY
Beats Per Minute (BPM)
66.3; 66.6
SECONDARY
Skin Conductance (μS)
3.58; 3.84
SECONDARY
Self-reported Positive Affect
12.0; 12.2
SECONDARY
Self-reported Stress
1.44; 1.57
SECONDARY
Self-reported Negative Affect
5.81; 5.92
SECONDARY
Levels of CRP
9.93; 13.6
SECONDARY
Levels of Cortisol in Serum (ng/mL)
117; 124
SECONDARY
Blood Pressure (Systolic in mmHg)
119; 117
SECONDARY
Level of TNF-alpha
4.03; 3.72
SECONDARY
Levels of Il-6
0.585; 0.591
SECONDARY
Baseline Blood Pressure (Diastolic in mmHg)
67.8; 66.1

Eligibility Criteria

Inclusion Criteria

  • 18 years and older
  • Non-smoker
  • Physically capable of walking for approximately 15-20 min from the study vehicle to the clinic and experimental locations.

Exclusion Criteria

  • Pregnancy
  • Current or prior diagnosis of neurologic, hypertensive, psychiatric, respiratory disorder, or anosmia/hyposmia
  • Some types of medication.
  • Olfactory sensitivity threshold (assessed via UPSIT® test kit (Sensonics International, Haddon Heights, NJ)

At enrollment, participants will complete a baseline survey on demographics, personality traits, and regular nature contact and perceptions. Study staff will also use the clinically-validated UPSIT® test kit (Sensonics International, Haddon Heights, NJ) to evaluate olfactory sensitivity and identify/exclude participants with undiagnosed smell loss.

Study staff will work with participants to schedule their forest bathing sessions and review instructions on how to prepare (e.g., by avoiding alcohol, marijuana, and certain foods, drinks, and household cleaning products with high terpene concentrations 24 hrs before their session).

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT05316597). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.

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