N/A
N=64
Cigarette and E-cigarette Nicotine Content in an Electronic Tobacco Marketplace (ETM)
Tobacco Use
Bottom Line
View on ClinicalTrials.gov: NCT05320887 ↗Enrolled (actual)
64
Serious AEs
0.0%
Results posted
Oct 2024
Primary outcome: Primary: Number of Cigarettes Purchased — 154.7; 119.2 average number of cigarettes
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Normal Nicotine Content Vape with all flavor e-liquids (Other); Normal nicotine content vape with tobacco e-liquids (Other); Low nicotine content vape with all flavor e-liquids (Other); Low nicotine content vape with tobacco e-liquids (Other)
- Age
- Adult, Older Adult · 21+ yrs
- Sex
- All
- Sponsor
- Wake Forest University Health Sciences
- Primary completion
- Jul 2023
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Number of Cigarettes Purchased |
154.7; 119.2 | — |
| SECONDARY Number of E-liquid Milliliters Purchased |
36.7; 35.0 | — |
| SECONDARY Proportion of Participants Completing Flavor and Nicotine Content Discrete Choice Projections |
41.8; 61.9 | — |
| SECONDARY Lung Cancer Perceived Risk Scores for VLNC Cigarettes |
5.4; 4.2 | — |
| SECONDARY Product Evaluation Scale Scores |
29.1; 29.1 | — |
| SECONDARY Minnesota Nicotine Withdrawal Scale Scores |
5.3; 4.9 | — |
| SECONDARY Questionnaire on Smoking Urges Score |
36.1; 32.4 | — |
| SECONDARY Tobacco Product Interest Scores |
87.2; 88.4; 27.1; 32.2; 38.3; 33.2 | — |
| SECONDARY Tobacco Policy Questionnaire Scores |
15; 11; 7; 11; 7; 10 | — |
Summary
This study is proposing a four condition Electronic Tobacco Marketplace (ETM) study to determine if banning normal nicotine content (NNC) is sufficient for encouraging smokers to switch to potentially less harmful products or if the availability of higher nicotine and/or flavored alternative products (specifically e-cigarettes) are needed to achieve maximal reductions in smoking.
Eligibility Criteria
Inclusion Criteria
- 21+ years of age
- Self-report smoking at least 5 cigarettes per day for the past year
- Breathe carbon monoxide (CO) level > 8 ppm or positive urine NicCheck
- Willingness to use other tobacco products during the study
- Speak, comprehend, and read English sufficiently to complete study procedures
- Have home access to a computer, smart phone, or tablet with a web camera and internet access
- Tried a vaping device at least once in their lifetime
Exclusion Criteria
- Currently seeking treatment to quit smoking
- Self-reported serious medical or psychiatric condition(s) including cardiovascular and chronic respiratory diseases
- Body temperature > 100.4 F
- Cold, flu or COVID-19 symptoms including fever, cough, and runny nose in the past 30 days
- Currently pregnant, breastfeeding or intending to become pregnant for the duration of the study or unwilling to agree to use adequate protection to avoid pregnancy
- CO reading > 80 ppm
Data sourced from ClinicalTrials.gov (NCT05320887). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.