N/A
N=142
Evaluation of Microcirculatory Function and Mitochondrial Respiration After Cardiovascular Surgery
Shock · Cardiovascular Diseases · Critical Illness
Bottom Line
View on ClinicalTrials.gov: NCT05330676 ↗Enrolled (actual)
142
Serious AEs
0.0%
Results posted
May 2024
Primary outcome: Primary: Perfused Vessel Denisty (PVD) — 22.8; 23.8; 20.2; 22.5 mm/mm^2
Study Design & Population
- Study type
- Observational
- Phase
- N/A
- Interventions
- coronary artery bypass grafting, valve repair/replacement (Procedure)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- University of Pennsylvania
- Primary completion
- Apr 2023
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Perfused Vessel Denisty (PVD) |
22.8; 23.8; 20.2; 22.5; 21.1; 22.8 | — |
Summary
This study will examine the differences in microcirculatory function and mitochondrial respiration in patients with shock after cardiovascular surgery.
Eligibility Criteria
Inclusion Criteria
- Adult patients (>18 years old)
- Receiving elective coronary artery bypass graft (CABG)
- Receiving valvular surgery requiring cardiopulmonary bypass
Exclusion Criteria
- Unable to tolerate sublingual microcirculatory flow imaging (e.g., non-intubated patients dependent upon oxygen by facemask, poor mouth opening)
- receiving an emergent procedure
- have an actively treated malignancy
- mitochondrial disorder
- receiving surgery requiring deep hypothermic circulatory arrest.
Data sourced from ClinicalTrials.gov (NCT05330676). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.