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Home › Conditions › Shock

Shock

3 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Shock

10 trials tracked for Shock: 3 in phase 3 or 4 and 1 with published results. The most-cited published study has 13 citations.

10Trials tracked
3Phase 3 & 4
0Recruiting
1With published results
Phase distribution
Phase 4 3 Phase 2 1 Other / NA 6
  1. Phase 4 Steroid Use in Pediatric Fluid and Vasoactive Infusion Dependent Shock - Pilot Study Completed · 13 cited
  2. Phase 4 Angiotensin II in the Perioperative Management of Hypotension in Kidney Transplant Recipients Completed
  3. Phase 4 Effect of Nebulized Bronchodilators on Heart Rate Completed
  4. Phase 2 Tranexamic Acid Mechanisms and Pharmacokinetics in Traumatic Injury Completed
  5. N/A Transcutaneous pO2, Transcutaneous pCO2 and Central Venous SO2 Variations to Define Fluid Responsiveness Completed
  6. N/A Impact of Early Enteral vs. Parenteral Nutrition on Mortality in Patients Requiring Mechanical Ventilation and Catecholamines Completed
Show 4 more trials
  1. N/A Optimal VAsopressor titraTION Pilot Randomized Controlled Trial Completed
  2. N/A Non-Invasive Ventilation Via a Helmet Device for Patients Respiratory Failure Completed
  3. N/A Evaluation of Microcirculatory Function and Mitochondrial Respiration After Cardiovascular Surgery Completed
  4. N/A NT-proBNP in ICU Postoperative/Posttraumatic Patients With Shock Completed

Showing the 10 most-cited and recently-updated of 10 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Shock: what the trials found

In the management of shock, hydrocortisone was evaluated in a study where 44% of patients had blood samples successfully received and analyzed for laboratory assessment 2.

Angiotensin II administration was observed to result in zero instances of thrombosis or peripheral/visceral ischemia, with only one patient (5%) experiencing an arrhythmia 3.

Levalbuterol was associated with a statistically significant reduction in heart rate (-0.16; 1.40, p=0.01) and a reported incidence of arrhythmias (0.33; 1.3, p=0.05), with a total of 2 to 3 participants experiencing arrhythmias (p=0).

Recent results — preliminary, needs further review

  • Enteral nutrition was evaluated in a large cohort (N=2410) as a potential intervention for shock 1.

For the clinician treating this condition

  • Angiotensin II showed no associated instances of thrombosis or peripheral/visceral ischemia in clinical observation 3.
  • Levalbuterol is associated with a statistically significant reduction in heart rate in patients experiencing shock 4.
  • Enteral nutrition is an emerging area of investigation for management in large patient populations 1.

AI synthesis of 4 cited trials, updated Jun 27, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Echocardiography guided by dynamic measures provides superior prediction of fluid responsiveness in shock management
Neurology Sys. Review
Echocardiography guided by dynamic measures provides superior prediction of fluid responsiveness in shock management Echo Guided Fluid Management Helps Identify Shock Treatment Needs
This narrative review synthesizes the role of echocardiography in guiding fluid resuscitation for adult patients with shock. The authors con…
Newer echocardiography methods help doctors decide how much fluid to give patients in shock while avoiding risks like lung congestion.
Frontiers Aug 22, 2026
Whole blood for prehospital transfusion did not reduce 30-day mortality compared to blood components
Drug Pipeline RCT
Whole blood for prehospital transfusion did not reduce 30-day mortality compared to blood components Trial shows no survival benefit for whole blood over components
This phase 3 cluster-randomized trial of 695 patients receiving whole blood and 298 receiving blood components found no statistically signif…
A large trial of trauma patients found that using whole blood instead of standard blood parts did not improve 30-day survival rates.
Jun 20, 2026
Meta-analysis of 34 Studies Shows Buffered Solutions Do Not Lower Mortality Compared to 0.9% Saline
Neurology Sys. Review
Meta-analysis of 34 Studies Shows Buffered Solutions Do Not Lower Mortality Compared to 0.9% Saline Saline vs. Balanced Fluids: What ICU Patients Really Need
This systematic review and meta-analysis of 34 studies involving 37,859 participants evaluated buffered solutions versus 0.9% saline in crit…
A major review finds no survival benefit for balanced IV fluids over standard saline in ICU patients, though kidney effects remain unclear.
Cochrane Apr 21, 2026