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Home › Conditions › Shock

Shock

2 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Shock

10 trials tracked for Shock: 3 in phase 3 or 4 and 1 with published results. The most-cited published study has 13 citations.

10Trials tracked
3Phase 3 & 4
0Recruiting
1With published results
Phase distribution
Phase 4 3 Phase 2 1 Other / NA 6
  1. Phase 4 Steroid Use in Pediatric Fluid and Vasoactive Infusion Dependent Shock - Pilot Study Completed · 13 cited
  2. Phase 4 Angiotensin II in the Perioperative Management of Hypotension in Kidney Transplant Recipients Completed
  3. Phase 4 Effect of Nebulized Bronchodilators on Heart Rate Completed
  4. Phase 2 Tranexamic Acid Mechanisms and Pharmacokinetics in Traumatic Injury Completed
  5. N/A Transcutaneous pO2, Transcutaneous pCO2 and Central Venous SO2 Variations to Define Fluid Responsiveness Completed
  6. N/A Impact of Early Enteral vs. Parenteral Nutrition on Mortality in Patients Requiring Mechanical Ventilation and Catecholamines Completed
Show 4 more trials
  1. N/A Optimal VAsopressor titraTION Pilot Randomized Controlled Trial Completed
  2. N/A Non-Invasive Ventilation Via a Helmet Device for Patients Respiratory Failure Completed
  3. N/A Evaluation of Microcirculatory Function and Mitochondrial Respiration After Cardiovascular Surgery Completed
  4. N/A NT-proBNP in ICU Postoperative/Posttraumatic Patients With Shock Completed

Showing the 10 most-cited and recently-updated of 10 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Shock: what the trials found

In the management of shock, hydrocortisone was evaluated in a study where 44% of patients had blood samples successfully received and analyzed for laboratory assessment 2.

Angiotensin II administration was observed to result in zero instances of thrombosis or peripheral/visceral ischemia, with only one patient (5%) experiencing an arrhythmia 3.

Levalbuterol was associated with a statistically significant reduction in heart rate (-0.16; 1.40, p=0.01) and a reported incidence of arrhythmias (0.33; 1.3, p=0.05), with a total of 2 to 3 participants experiencing arrhythmias (p=0).

Recent results — preliminary, needs further review

  • Enteral nutrition was evaluated in a large cohort (N=2410) as a potential intervention for shock 1.

For the clinician treating this condition

  • Angiotensin II showed no associated instances of thrombosis or peripheral/visceral ischemia in clinical observation 3.
  • Levalbuterol is associated with a statistically significant reduction in heart rate in patients experiencing shock 4.
  • Enteral nutrition is an emerging area of investigation for management in large patient populations 1.

AI synthesis of 4 cited trials, updated Jun 27, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Whole blood for prehospital transfusion did not reduce 30-day mortality compared to blood components
Drug Pipeline RCT
Whole blood for prehospital transfusion did not reduce 30-day mortality compared to blood components Trial shows no survival benefit for whole blood over components
This phase 3 cluster-randomized trial of 695 patients receiving whole blood and 298 receiving blood components found no statistically signif…
A large trial of trauma patients found that using whole blood instead of standard blood parts did not improve 30-day survival rates.
Jun 20, 2026
Meta-analysis of 34 Studies Shows Buffered Solutions Do Not Lower Mortality Compared to 0.9% Saline
Neurology Sys. Review
Meta-analysis of 34 Studies Shows Buffered Solutions Do Not Lower Mortality Compared to 0.9% Saline Saline vs. Balanced Fluids: What ICU Patients Really Need
This systematic review and meta-analysis of 34 studies involving 37,859 participants evaluated buffered solutions versus 0.9% saline in crit…
A major review finds no survival benefit for balanced IV fluids over standard saline in ICU patients, though kidney effects remain unclear.
Cochrane Apr 21, 2026