Phase 4
N=35
Effect of Post-Operative Anesthetics on Post-Operative Pain in Patients Receiving Endodontic Treatment
Endodontic Disease · Post Operative Pain · Symptomatic Irreversible Pulpitis
Bottom Line
View on ClinicalTrials.gov: NCT05338671 ↗Enrolled (actual)
35
Serious AEs
0.0%
Results posted
May 2025
Primary outcome: Primary: Post-operative Pain Level 6 Hours on a Visual Analog Scale — 64.2; 43.1 units on a scale
Study Design & Population
- Study type
- Interventional
- Phase
- Phase 4
- Interventions
- Local anesthetic (Drug)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- University of Washington
- Primary completion
- Jun 2024
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Post-operative Pain Level 6 Hours on a Visual Analog Scale |
64.2; 43.1 | — |
| PRIMARY Post-operative Pain Level 12 Hours on a Visual Analog Scale |
67.4; 45.1 | — |
| PRIMARY Post-operative Pain Level 24 Hours on a Visual Analog Scale |
48.9; 36.5 | — |
| PRIMARY Post-operative Pain Level 48 Hours on a Visual Analog Scale |
45.3; 30.1 | — |
| PRIMARY Post-operative Pain Level 72 Hours on a Visual Analog Scale |
35.5; 21.9 | — |
Summary
This study will assess the efficacy of two local anesthetics (2% lidocaine 1:100,000 epinephrine and 0.5% bupivicaine 1:200,000 epinephrine) in reducing post-operative pain in patients receiving endodontic treatment.
Eligibility Criteria
Inclusion Criteria
- Diagnosis of symptomatic irreversible pulpitis on mandibular, posterior tooth
- ASA I or II
- >18 years old
Exclusion Criteria
- Maxillary or mandibular anterior tooth
- Diagnosis of pulp necrosis or reversible pulpitis
- Tooth deemed non-restorable
- <18 years old
- ASA III, IV, or V
- Patients who are contraindicated to take ibuprofen
- Patients with allergies to any medications being assessed in this study
Data sourced from ClinicalTrials.gov (NCT05338671). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.