N/A N=45 Adjunctive Steps for Disinfection of Teeth With Primary Endodontic Infections
Periapical Periodontitis · Bacterial Infections
Primary: Metabolic Activity of Persistent Bacteria — 4.748; 2.57; 2.614; 4.0008 RNA/DNA ratio
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=4 Nanodiamond Modified Gutta Percha (NDGP) Composite for Non-surgical Root Canal Therapy (RCT) Filler Material
Dental Pulp Diseases · Dental Pulp Necrosis · Nerve Root Pain Nec
Primary: Percent Reduction in Apical Radio-lucency — 17.4; 27.1 % Change in Diameter (mm)
N/A N=194 Post-endodontic Pain Survey
Postoperative Pain · Endodontic Disease · Obturation
Primary: Visual Analogue Scale (VAS) — 4.06; 2.68; 2.41; 2.27 score on a scale
N/A N=108 Effect of Root Canal Treatment (Versus no Treatment) for Patients With Tooth Infections and Toothaches
Postoperative Pain
Primary: Percent of Patients With Success as Defined by no or Mild Pain as Analyzed on a VAS Scale and no Narcotic Use — 52; 43 percentage of participants
N/A N=132 Effects of Different Irrigation Activation Techniques on the Healing of Large Periapical Lesions
Periapical Periodontitis · Irrigation Activation · Lasers
Primary: Post-operative Diameter of the Periapical Lesion — 2.07; 0.98; 1.12; 0.78 Post-operative lesion diameter- mm2
N/A N=86 Bone Regenerative Techniques in Endodontic Microsurgery
Apical Periodontitis
Primary: 2D Radiographic Healing at 12 Months Follow up (Overall Cases) — 24; 29; 1; 1 osteotomy site
N/A N=36 Encapsulated Mesenchymal Stem Cells for Dental Pulp Regeneration.
Periapical Periodontitis
Primary: Number of Participats Showing Efficacy (Functionality) — 18; 18 Participants
N/A N=69 Sonendo GentleWave™ System for Treatment in Molar Teeth Requiring Root Canal Therapy
Root Canal Therapy
Primary: Number of Participants With a PAI Score of < 3, = 3, or = 4 or 5 — 51; 3; 0 Participants
N/A N=32 Effects of Photobiomodulation on Postoperative Pain After Primary Endodontic Therapy in Molars With Symptomatic Apical Periodontitis
Postoperative Pain
Primary: Pain as Assessed by the Visual Analog Scale — 0; .33 score on a scale
Phase 4 N=41 EMD and/or Bone Substitute for the Treatment of Class II Furcations
Periodontal Disease
Primary: Relative Horizontal Clinical Attachment Level (RHCAL) at 12 Months — 2.31; 3.00; 2.57 mm
N/A N=60 Antimicrobial Efficacy of Four Different Irrigation Protocols
Dental Pulp Necrosis
Primary: Number of Colony Forming Units Per Millilitre — 80300000; 79900000; 74000000; 73000000 CFU/ml
Phase 3 N=102 Periodontal Infection and Endothelial Dysfunction
Periodontitis
Primary: Brachial Artery Flow-mediated Dilation — 10.2; 10.3; 13.1; 8.1 Percentage of dilatation of brachial art — p=0.98
N/A N=15 A New Approach for Controlling Hemostasis During Canal Treatment: a Pilot Study
Blood Contamination of Root Canal During Endodontic Therapy
Primary: Change From Baseline in Root Canal Bleeding Score — 2.33; 0.13 score on a scale — p=<.0001
N/A N=5,117 Periodontal Disease Prevention Study
Periodontitis
Primary: Percentage of Participants With Tooth Loss Over 16 Year Period — 16.4; 13.8; 22.1; 16.9 percentage of participants
N/A N=160 Comparative Evaluation of Post-endodontic Pain Using Two Rotary Instrumentation Systems
Pain
Primary: Post-operative Pain on the Visual Anlogue Scale (VAS) at the 6-hour Post-operative Interval — 5; 3.2; 3.5 units on a scale
Phase 2 N=24 Use of Mineral Trioxide Aggregate in the Treatment of Traumatized Teeth
Periapical Diseases
Primary: Changes Between Initial and Post Treatment Dimensions of Periapical Lesions — 37.34; 34.04; 16.20; 17.54 square millimeters — p=<0.01
N/A N=60 Survival of Endocrowns Made From Different Ceramics
Pulp Disease, Dental · Dental Caries · Dental Leakage
Primary: Survival of Dental Prosthesis — 19; 14; 17 Teeth
Phase 3 N=602 Periocline as an Adjunct to Scaling and Root Planing for Adult Periodontitis
Adult Periodontitis
Primary: Change in Pocket Depth. — -1.4; -1.6; -1.4 mm
N/A N=63 Postoperative Pain and Healing in Teeth Treated With GentleWave or EndoActivator
Symptomatic Irreversible Pulpitis · Apical Periodontitis
Primary: 24 Hour Postoperative Pain for Patients Seen From 09/2020-06/2021 — 14.75; 16.23 score on a scale — p=0.63
Phase 4 N=64 Assessing Success of MTA and Pre-mixed Bioceramic in Mature Teeth With Irreversible Pulpitis With Full Pulpotomy.
Pulpitis - Irreversible
Primary: Clinical Success at 6 Months — 27; 30 Participants
N/A N=50 Effect of Passive Ultrasonic Irrigation on the Reduction of Bacteria and Endotoxins in Root Canals
Tooth, Nonvital
Primary: Bacterial Levels — 4290; 10800 DNA copies — p=0.04
Phase 3 N=80 Role of Propolis Paste in Preventing Pain After Root Canal Treatment.
Pain, Postoperative
Primary: Pain Intensity Measure: Visual Analogue Pain Scale — 11.8; 8.8; 9.4; 10.3 score on a scale — p=0.329
N/A N=60 Effect of Cryotherapy on Post-endodontic Pain
Cryotherapy
Primary: The Level of Post-endodontic Pain — 1.85; 2.15; 3.65 score on a scale — p=0.986
Phase 3 N=983 Prevention of Adult Caries Study (PACS)
Caries, Dental
Primary: Total Net D12FS Caries Increment (Total of Non-cavitated Lesions (D1), Cavitated Lesions (D2) and Sound Surfaces (S)) — 2.43; 2.68 weighted increment units/13 months…
N/A N=98 Clinical Comparison of Vital Pulp Capping Restorative Protocols
Deep Dental Caries
Primary: Success Rate Based on Pulp Vitality Tests (Vital/Non Vital) — 96.2; 100; 100; 86 Percentage of success rate — p=>0.1
N/A N=30 Implant Surface Decontamination in Peri-implantitis Treatment
Peri-implantitis · Periodontal Disease
Primary: Change in Total Bacterial Load on the Exposed Implant Surface — 2.77; 4.21 log (colony forming units/ml)
N/A N=51 Kidney and Periodontal Disease Study
Chronic Kidney Disease · Periodontal Disease
Primary: Number of Participants Completing Study Protocol — 17; 34; 14; 30 Participants
N/A N=40 Clinical and Microbiologic Outcomes of Adjunctive Antimicrobial Photodynamic Therapy in the Non-surgical and Surgical Treatment of Teeth With Periodontal Disease
Periodontal Diseases
Primary: Change in Number of Bleeding Sites (Bleeding On Probing) — -1.60; -1.40 bleeding sites
N/A N=70 Effect of Irrigation-Activation Techniques on Healing in Large Periapical Lesions
Effect of Irrigation Activation on Periapical Healing
Primary: Percentage Change in Lesion Volume at 12-months Follow-up — 80.429; 85.429; 86.929; 74.571 percent change — p=<0.05
Phase 3 N=169 Calcium Hydroxide, Mineral Trioxide Aggregate and Biodentine (Trademark) as Direct Pulp Capping of Permanent Teeth
Caries · Dental Pulp Exposure
Primary: Parameters Evaluated After Treatment — 19; 19; 25; 3 Participants