N/A
Completed N=8
Monocyte Priming When Consuming a Western Diet
Source: ClinicalTrials.gov NCT05348395 ↗Enrolled (actual)
8
Serious AEs
0.0%
Results posted
Mar 2026
Primary outcomePrimary: Measurement of Mitogen-activated Protein Kinase Phosphate 1 (MKP-1) Activity — 6.71 ng/mg protein
Summary
To determine the mechanism of monocyte priming in humans, the study team will conduct a complete feeding trial in normal weight and metabolically healthy human subjects (20-45 years of age) using a western diet (WD), characterized as being high-saturated fat, high-fructose, and high-calorie for 8 weeks.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Measurement of Mitogen-activated Protein Kinase Phosphate 1 (MKP-1) Activity |
5.91 | — |
| PRIMARY Measurement of Mitogen-activated Protein Kinase Phosphate 1 (MKP-1) Activity |
5.91 | — |
| SECONDARY Ribonucleic Acid (RNA) Analysis |
— | — |
Eligibility Criteria
Inclusion Criteria
- Age 20-45
- Planning to be available for the entire study period
- Able to speak and read English
- Normal weight (body mass index 18.5-24.9 kg/m2)
- Able to eat the prescribed diet
- Non-smoker
Exclusion Criteria
- Excessive alcohol consumption
- History of chronic cardiometabolic disease or major risk factor, including diabetes, hypertension, hyperlipidemia, heart disease
- History of prior surgical procedure for weight control or liposuction
- Use of weight loss medications in previous 6 months
- Recent self-reported weight change
- Severe pulmonary disease requiring supplemental oxygen
- Abnormal renal or liver function
- History of non-skin cancer in the past 5 years
- Regular use of medications (prescribed or over-the-counter) that affect blood pressure, lipids, glucose, inflammation, or body weight
- Works night shifts
- Exercise per week > 420 minutes total for moderate activity or > 210 minutes for vigorous activity
- Any medical or behavioral indication that would make participation unsafe based on the judgement of the study physician
- Pregnant or lactating women
- Known or discovered intolerances, allergies or difficulty consuming any of the foods included in the study diets
Data sourced from ClinicalTrials.gov (NCT05348395). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.