N/A
Completed N=78
Onboarding Positives and PrEP Users to Engage Negatives (OPPEN): Peer-driven Education to Link YMSM of Color to PrEP
Source: ClinicalTrials.gov NCT05356910 ↗Enrolled (actual)
78
Serious AEs
0.0%
Results posted
Jul 2025
Primary outcomePrimary: PrEP Interest (Peer-Recruit Participants) — 2; 3 Participants
Summary
Onboarding Positives and PrEP users to Engage Negatives (OPPEN) is an intervention to train young men who have sex with men (YMSM) of color living with HIV or using pre-exposure prophylaxis (PrEP) to promote PrEP use among HIV-negative YMSM of color in their social networks. This pilot randomized controlled trial will evaluate OPPEN's acceptability, feasibility, and preliminary effect on PrEP care engagement among YMSM of color.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY PrEP Interest (Peer-Recruit Participants) |
2; 3 | — |
| PRIMARY PrEP Linkage (Peer-Recruit Participants) |
1; 2 | — |
| PRIMARY PrEP Uptake (Peer-Recruit Participants) |
1; 2 | — |
| SECONDARY PrEP Conversations With Peers (Index Participants) |
15; 9 | — |
| SECONDARY PrEP Information (Peer-Recruit Participants) |
9.0; 5.7 | — |
| SECONDARY PrEP Motivation (Peer-Recruit Participants) |
85.5; 77.8 | — |
| SECONDARY PrEP Behavioral Skills (Peer-Recruit Participants) |
30.5; 23.5 | — |
| SECONDARY Session Acceptability (Index Participants) |
4.5; 4.3 | — |
| SECONDARY Session Feasibility (Index Participants) |
4.2; 3.9 | — |
| SECONDARY Acceptability of Interaction With Referring Index (Peer-Recruit Participants) |
4.7; 3.6 | — |
| SECONDARY Feasibility of Interaction With Referring Index (Peer-Recruit Participants) |
4.5; 4.0 | — |
Eligibility Criteria
Inclusion Criteria (Index Participants):
- 18-34 years-old
- Cisgender male
- Fluent in English
- Person of color
- Engaged in HIV care or PrEP care
- Sexual activity with cisgender men or transgender women in their lifetime
- Social networks with at least three 18-34 year-old MSM peers of color
- Willing to disclose their HIV status or PrEP use to their 18-34 year-old MSM peers of color
- Willing to provide written informed consent
Inclusion Criteria (Peer-Recruit Participants):
- 18-34 years-old
- Cisgender male
- Fluent in English or Spanish
- Person of color
- HIV-negative
- Not using PrEP
- Sexual activity with cisgender men or transgender women in their lifetime
- Willing to provide written informed consent
Exclusion Criteria
- Persons who meet the criteria above will be eligible, no other exclusion criteria will apply.
Data sourced from ClinicalTrials.gov (NCT05356910). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.