N/A
N=60
Effect of Beetroot Juice on Reducing Hypertension in Autosomal Dominant Polycystic Kidney Disease
Autosomal Dominant Polycystic Kidney · Hypertension · Endothelial Dysfunction
Bottom Line
View on ClinicalTrials.gov: NCT05401409 ↗Enrolled (actual)
60
Serious AEs
0.0%
Results posted
Jun 2025
Primary outcome: Primary: Change in Clinic Systolic and Diastolic Blood Pressure From Baseline to 4 Weeks (End of Study) — -5.36; -7.65; -3.55; -2.73 mmHg
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Beetroot juice (Dietary_supplement); Nitrate-depleted beetroot juice (Dietary_supplement)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- Western Sydney Local Health District
- Primary completion
- Mar 2023
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Change in Clinic Systolic and Diastolic Blood Pressure From Baseline to 4 Weeks (End of Study) |
-5.36; -7.65; -3.55; -2.73 | — |
| SECONDARY Average Change in Daily Home Systolic and Diastolic Blood Pressure Per Week, Over 4 Weeks |
-0.51; -0.55; -0.24; -0.47 | — |
| SECONDARY Urinary Albumin to Creatinine Ratio at Baseline and at 4 Weeks (End of Study) |
2.2; 3.9; 2.5; 3.6 | — |
| SECONDARY Change in Serum Nitric Oxide Metabolite Levels From Baseline to 4 Weeks (End of the Study) |
20.08; 0.97 | — |
| SECONDARY Change in Salivary Nitric Oxide Metabolite Levels From Baseline to 4 Weeks (End of the Study) |
— | — |
| SECONDARY Serum Asymmetric Dimethylarginine at Baseline and at 4 Weeks (End of the Study) |
0.47; 0.47; 0.50; 0.52 | — |
Summary
People with autosomal dominant polycystic kidney disease (ADPKD) develop high blood pressure and kidney disease. Previous studies have shown that a commonly occurring chemical, nitric oxide (NO), is reduced in ADPKD, and may contribute, in part, to high blood pressure in this condition. Nitrate is found in high concentrations naturally in beetroots, and increases NO. The aim of this study is to determine if beetroot juice reduces blood pressure in hypertensive people with ADPKD.
Eligibility Criteria
Inclusion Criteria
- Diagnosis of Autosomal Dominant Polycystic Kidney Disease
- Age > 18 years old
- Estimated Glomerular Filtration Rate (eGFR) > 30 mL/min/1.73m2
- Treatment with at least one anti-hypertensive
Exclusion Criteria
- Inability to provide Informed Consent
- Labile, unstable, uncontrolled hypertension and/or changes in BP treatment 28 days prior to the screening visit
- Non-compliance with study procedures and/or daily BP measurements during the screening period
- Medical conditions or treatments that might interfere with the generation of NO metabolites or the primary endpoint (e.g. nitrate drugs; cigarette smoking; unwilling to stop using antiseptic mouthwash; severe, uncontrolled hypercholesterolemia; pregnancy or post-partum and lactating)
- Any serious or other medical conditions that might interfere with follow-up or stability of blood pressure (e.g. current active malignancies; uncontrolled diabetes mellitus with elevated HbA1c > 10%)
- Dislike of taste of beetroot juice
- Allergy to beetroot
- Enrolled in other clinical trials
Data sourced from ClinicalTrials.gov (NCT05401409). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.