N/A
Completed N=36
Autonomic Neuromodulation by Transcutaneous Nerve Stimulation in Acute Ischaemic Stroke.
Stroke · Thrombotic Stroke · Autonomic Dysfunction · Autonomic Imbalance
Source: ClinicalTrials.gov NCT05417009 ↗
Enrolled (actual)
36
Serious AEs
0.0%
Results posted
Jul 2025
Primary outcomePrimary: Blood Pressure Variability — 0.106; 0.107 coefficient of variation
Summary
Autonomic modulation by transcutaneous vagal nerve stimulation in acute ischaemic stroke requiring mechanical thrombectomy: a phase IIa, sham controlled randomised trial.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Blood Pressure Variability |
0.106; 0.107 | — |
| SECONDARY Systolic Blood Pressure Variability. |
14; 14 | — |
| SECONDARY Diastolic Blood Pressure Variability |
0.136; 0.127 | — |
Eligibility Criteria
Inclusion Criteria
- Undergoing mechanical thrombectomy for acute ischaemic stroke requiring general or sedation.
- Established hypertensive and/or hypertensive on admission for mechanical thrombectomy [systolic BP >140mmHg; diastolic BP >80mmHg]
Exclusion Criteria
- Current participation in a clinical trial of a treatment with a similar biological mechanism.
- Previous enrolment into VANS trial.
- Anatomical or other contraindication to trans-cutaneous auricular sensory stimulation
- Pregnancy.
Data sourced from ClinicalTrials.gov (NCT05417009). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.