N/A N=36 Randomized Double-blind Treatment

Autonomic Neuromodulation by Transcutaneous Nerve Stimulation in Acute Ischaemic Stroke.

Ischemic Stroke · Thrombotic Stroke · Autonomic Dysfunction · Autonomic Imbalance

Bottom Line

View on ClinicalTrials.gov: NCT05417009 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Jul 2025

Primary outcome: Primary: Blood Pressure Variability — 0.106; 0.107 coefficient of variation

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: trans-cutaneous auricular sensory stimulation (Device)
Age: Adult, Older Adult · 18+ yrs
Sex: All
Sponsor: Queen Mary University of London
Primary completion: Jul 2023

Outcome Measures

Outcome	Result	p-value
PRIMARY Blood Pressure Variability	0.106; 0.107	—
SECONDARY Systolic Blood Pressure Variability.	14; 14	—
SECONDARY Diastolic Blood Pressure Variability	0.136; 0.127	—

Summary

Autonomic modulation by transcutaneous vagal nerve stimulation in acute ischaemic stroke requiring mechanical thrombectomy: a phase IIa, sham controlled randomised trial.

Eligibility Criteria

Inclusion Criteria

Undergoing mechanical thrombectomy for acute ischaemic stroke requiring general or sedation.
Established hypertensive and/or hypertensive on admission for mechanical thrombectomy [systolic BP >140mmHg; diastolic BP >80mmHg]

Exclusion Criteria

Current participation in a clinical trial of a treatment with a similar biological mechanism.
Previous enrolment into VANS trial.
Anatomical or other contraindication to trans-cutaneous auricular sensory stimulation
Pregnancy.

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT05417009). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.