N/A
N=31
Activity, Adiposity, and Appetite in Adolescents 2 Intervention
Obesity · Energy Balance · Appetite · Metabolism · Insulin Sensitivity
Bottom Line
View on ClinicalTrials.gov: NCT05443347 ↗Enrolled (actual)
31
Serious AEs
0.0%
Results posted
Feb 2026
Primary outcome: Primary: Appetite- Subjective — 6282; 8738 score*minute
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Aerobic exercise (Behavioral); Newsletter (Behavioral)
- Age
- Pediatric · 14+ yrs
- Sex
- All
- Sponsor
- Children's Mercy Hospital Kansas City
- Primary completion
- Nov 2024
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Appetite- Subjective |
6282; 8738 | — |
| PRIMARY Appetite- Objective |
— | — |
| PRIMARY Appetite- Adjusted |
7482; 8269 | — |
Summary
The objective of the study is to quantify the relationship between physical activity, metabolic function, and appetite in adolescents. To do this we will test our working hypothesis that high levels of regular moderate-to-vigorous physical activity (MVPA), as opposed to body weight status, results in a metabolic phenotype consisting of enhanced metabolic function and proper regulation of appetite. We will randomly assigning sedentary overweight/obese adolescents (N=44) to either a control or structured-exercise group for three months.
Eligibility Criteria
Inclusion Criteria
- Tanner Stage III-V, as determined via self-assessment
- Non-smoking
- Not currently involved in any other research study
- No meds that may alter metabolism
- Sedentary ( 99th percentile for age and sex
- Weight not stable
- Restrained eater (>13 on the restraint section of the three-factor eating questionnaire; Current/past diagnosis of an eating disorder.
- Self-reported medical conditions (including, but not limited to, diabetes, Crohn's disease, etc.) that may affect adherence to the protocol, exercising safely, or alter metabolism
- Taking medications know to affect metabolism (e.g. thyroid medication, β-blockers, or stimulants).
- Gave birth in the past 12 months or 60 min/day exercise)
- Not willing to participate in an exercise program
Data sourced from ClinicalTrials.gov (NCT05443347). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.