N/A N=40 Randomized Quadruple-blind Prevention

Preventing Cognitive Decline

Cognitive Decline

Bottom Line

View on ClinicalTrials.gov: NCT05446909 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Oct 2024

Primary outcome: Primary: Percentage of Trials Correct On Working Memory Test — 87.69; 91.57; 88.01; 91.68 percentage of correct trials — p=>0.05

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: IBMT mindfulness (Behavioral); health education (Behavioral)
Age: Adult, Older Adult · 40+ yrs
Sex: All
Sponsor: Arizona State University
Primary completion: Feb 2023

Outcome Measures

Outcome	Result	p-value
PRIMARY Percentage of Trials Correct On Working Memory Test	87.69; 91.57; 88.01; 91.68	>0.05
PRIMARY Intervention Effects on Cognitive Decline	5.34; 4.96; 5.29; 4.87	>0.05
PRIMARY Intervention Effects on Emotion Regulation	5.71; 5.23; 5.50; 4.94	>0.05
PRIMARY Intervention Effects on Mindfulness	2.92; 2.87; 3.92; 3.39	<0.05 sig
SECONDARY Intervention Effects on Brain Function	0.47; 0.51; 0.53; 0.49	0.754
SECONDARY Intervention Effects on Brain White Matter	0.42; 0.39; 0.43; 0.37	0.985
SECONDARY Intervention Effects on Brain Grey Matter	589.23; 569.39; 570.42; 576.87	0.877

Summary

The study aims to understand the mechanisms and training effects of evidence-based body-mind training on improving cognitive performance and preventing cognitive decline.

Eligibility Criteria

Inclusion Criteria

Able to read/understand English
Normal performance using standardized cognitive tests
Self-reported decline in cognitive capacity such as memory loss
Eligible for non-invasive fMRI
Willing to be randomized
Free of any severe psychiatric diagnoses or medication that may affect participation

Exclusion Criteria

Medical disorders or medications that affect the central and autonomic nervous system; or a positive pregnancy test result (females)
Unable to provide consent or understand study procedures due to mental illness or cognitive limitations
Previous meditation experiences
Evidence of illicit drug use
Participants for blood draws weigh less than 110 lbs
Metal or metallic materials in the body such as pacemaker

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT05446909). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.