N/A
Completed N=3
Home-based Transcranial Direct Current Stimulation (tDCS) for Behavioral Symptoms in Alzheimer's Disease and Related Dementias (ADRD)
Source: ClinicalTrials.gov NCT05478681 ↗Enrolled (actual)
3
Serious AEs
—
Results posted
Oct 2025
Primary outcomePrimary: Acceptability of the tDCS Treatment as Assessed by the tDCS Acceptability Questionnaire
Summary
The purpose of this study is to assess acceptability, and safety of providing tDCS to ADRD patients with behavioral symptoms and to assess the efficacy of tDCS for ADRD-related symptoms, mainly behavioral symptoms.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Acceptability of the tDCS Treatment as Assessed by the tDCS Acceptability Questionnaire |
— | — |
| PRIMARY Safety as Assessed by the Side Effects Questionnaire |
— | — |
| SECONDARY Dementia-related Behavioral Symptoms as Assessed by the Neuropsychiatric Inventory (NPI-Q) Scale |
— | — |
| SECONDARY Apathy as Assessed by the Brief Dimensional Apathy Scale (b-DAS) |
— | — |
| SECONDARY Depressive Symptoms as Assessed by the Cornell Scale for Depression in Dementia (CSDD) |
— | — |
| SECONDARY Cognition as Evaluated by the Mini-Mental State Examination (MMSE) |
— | — |
Eligibility Criteria
Inclusion Criteria
- have ADRD and clinically-meaningful behavioral symptoms
- have a caregiver willing to participate in the study
- can speak and read English
- have stable doses of medications for at least one month
Exclusion Criteria
- any unstable concurrent medical conditions
- history of brain surgery
- seizure
- intracranial metal implantation
- current alcohol/substance use disorder
Data sourced from ClinicalTrials.gov (NCT05478681). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.