N/A
N=72
Comparison of Total Oxidant and Total Antioxidant Capacities in Low-Flow and High-Flow General Anesthesia
Oxidative Stress · Anesthesia
Bottom Line
View on ClinicalTrials.gov: NCT05590312 ↗Enrolled (actual)
72
Serious AEs
0.0%
Results posted
Jan 2025
Primary outcome: Primary: Comparison of Total Antioxidant Status (TAS) Levels Between the Two Groups — 1.76; 1.82; 1.83; 1.92 mmol Eq / L
Study Design & Population
- Study type
- Observational
- Phase
- N/A
- Interventions
- general anesthesia (Other)
- Age
- Adult · 18+ yrs
- Sex
- All
- Sponsor
- Duzce University
- Primary completion
- Nov 2023
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Comparison of Total Antioxidant Status (TAS) Levels Between the Two Groups |
1.76; 1.82; 1.83; 1.92; 1.85; 1.89 | — |
| PRIMARY Change From Baseline in Total Oxidant Status (TOS) Levels |
19.82; 21.48; 19.66; 17.20; 22.49; 21.38 | — |
| PRIMARY Change From Baseline in Albumin Levels. |
4.24; 4.15; 4.05; 4.02; 3.96; 3.97 | — |
| PRIMARY Change From Baseline in C Reactive Protein (CRP) Levels. |
0.30; 0.53; 0.31; 0.52; 1.41; 1.37 | — |
| PRIMARY Comparison of Vitamin D Levels Between the Two Groups |
7.5; 14.8 | — |
Summary
The goal of this observational study is to determine whether low-flow anesthesia has a positive contribution to the total oxidant/antioxidant balance.
Eligibility Criteria
Inclusion Criteria
- Patients older than 18 years and younger than 60 years of age who will be operated under general anesthesia
- Patients in I, II risk groups according to the American Society of Anesthesiologists (ASA) classification
Exclusion Criteria
- ASA III and above patients,
- Patients for whom Intensive Care Unit (ICU) indication is required
- Chronic obstructive pulmonary disease,
- Personal or family history of malignant hyperthermia,
- Morbid obesity,
- Alcohol or drug dependency,
- Having a history of liver or kidney disease,
- Having coronary artery disease or heart failure,
- Having significant anemia or hemoglobinopathy,
- Hypotension, hypovolemia, sepsis.
Data sourced from ClinicalTrials.gov (NCT05590312). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.