N/A
N=95
Assessing the Feasibility of Economic Approaches to Prevent Substance Abuse Among Adolescents
Adolescent Drinking · HIV/AIDS · Drug Use
Bottom Line
View on ClinicalTrials.gov: NCT05597865 ↗Enrolled (actual)
95
Serious AEs
0.0%
Results posted
Dec 2025
Primary outcome: Primary: Percentage of Participants Completing the Study at 6 Months — 44; 46 Participants
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Economic Empowerment Intervention (Behavioral); Alcohol and Drug Use Risk Reduction Sessions (Behavioral)
- Age
- Adult · 18+ yrs
- Sex
- All
- Sponsor
- Washington University School of Medicine
- Primary completion
- Jun 2024
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Percentage of Participants Completing the Study at 6 Months |
44; 46 | — |
| PRIMARY Number of Participants Enrolling in the Study at Baseline |
44; 46 | — |
| SECONDARY Percentage of Participants That Self-reported Use of Any Drug in the Last 3 Months at the Baseline Assessment |
25; 31 | — |
| SECONDARY Percentage of Participants That Self-reported Use of Any Drug in Last 3 Months at the 6-month Assessment |
21; 24 | — |
| SECONDARY Optimism Scale Total Score at Baseline |
38.5; 38.8 | — |
| SECONDARY Optimism Scale Total Score at 6 Months |
39.5; 39.3 | — |
| SECONDARY Beck Hopelessness Scale Total Score at Baseline |
4.6; 5.2 | — |
| SECONDARY Beck Hopelessness Scale Total Score at 6 Months |
5.2; 4.4 | — |
| SECONDARY Depressive Symptoms Total Score at Baseline |
38.1; 37.6 | — |
| SECONDARY Depressive Symptom Total Score at 6 Months |
37.6; 37.1 | — |
| SECONDARY Percentage of Participants That Self-reported Use of Any Drug in Last 12 Months at the Baseline Assessment |
34; 39 | — |
| SECONDARY Percentage of Participants That Self-reported Use of Any Drug in Last 12 Months at 6 Month Assessment |
32; 28 | — |
| SECONDARY Percentage of Participants That Self-reported Use of Alcohol in Last 12 Months at Baseline |
31; 35 | — |
| SECONDARY Percentage of Participants That Self-reported Use of Alcohol in Last 12 Months at the 6-month Assessment |
29; 26 | — |
| SECONDARY Percentage of Participants With a Positive Urine Test for Any Drug at Baseline |
15; 24 | — |
| SECONDARY Percentage of Participants With a Positive Urine Test for Any Drug at the 6-month Assessment |
11; 15 | — |
| SECONDARY Percentage of Participants With a Positive Urine Test for Alcohol at the Baseline Assessment |
8; 20 | — |
| SECONDARY Percentage of Participants With a Positive Urine Test for Alcohol at the 6-month Assessment |
8; 12 | — |
Summary
The proposed study will test the impact of an economic empowerment intervention on reducing alcohol and drug use (ADU) among adolescents and youth living with HIV (AYLHIV) in poverty-impacted communities in Uganda. It focuses on improving understanding of multi-level context- specific risk and protective factors for ADU among AYLHIV.
Eligibility Criteria
Inclusion Criteria for AYLHIV:
- male or female AYLHIV aged 15-24 years;
- medically diagnosed with HIV and aware of their HIV status;
- enrolled in care at one of the selected HIV clinics.
- positive self-report or urine test for alcohol or drug use
Exclusion Criteria
- any AYLHIV with negative urine alcohol or drug use test and negative self-report for alcohol and drug use
- anyone with a significant cognitive impairment that interferes with their understanding of the informed consent process, or is unable/unwilling to consent.
Data sourced from ClinicalTrials.gov (NCT05597865). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.