N/A
Completed N=95
Assessing the Feasibility of Economic Approaches to Prevent Substance Abuse Among Adolescents
Adolescent Drinking · HIV · Drug Use
Source: ClinicalTrials.gov NCT05597865 ↗
Enrolled (actual)
95
Serious AEs
0.0%
Results posted
Dec 2025
Primary outcomePrimary: Percentage of Participants Completing the Study at 6 Months — 44; 46 Participants
Summary
The proposed study will test the impact of an economic empowerment intervention on reducing alcohol and drug use (ADU) among adolescents and youth living with HIV (AYLHIV) in poverty-impacted communities in Uganda. It focuses on improving understanding of multi-level context- specific risk and protective factors for ADU among AYLHIV.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Percentage of Participants Completing the Study at 6 Months |
44; 46 | — |
| PRIMARY Number of Participants Enrolling in the Study at Baseline |
44; 46 | — |
| SECONDARY Percentage of Participants That Self-reported Use of Any Drug in the Last 3 Months at the Baseline Assessment |
25; 31 | — |
| SECONDARY Percentage of Participants That Self-reported Use of Any Drug in Last 3 Months at the 6-month Assessment |
21; 24 | — |
| SECONDARY Optimism Scale Total Score at Baseline |
38.5; 38.8 | — |
| SECONDARY Optimism Scale Total Score at 6 Months |
39.5; 39.3 | — |
| SECONDARY Beck Hopelessness Scale Total Score at Baseline |
4.6; 5.2 | — |
| SECONDARY Beck Hopelessness Scale Total Score at 6 Months |
5.2; 4.4 | — |
| SECONDARY Depressive Symptoms Total Score at Baseline |
38.1; 37.6 | — |
| SECONDARY Depressive Symptom Total Score at 6 Months |
37.6; 37.1 | — |
| SECONDARY Percentage of Participants That Self-reported Use of Any Drug in Last 12 Months at the Baseline Assessment |
34; 39 | — |
| SECONDARY Percentage of Participants That Self-reported Use of Any Drug in Last 12 Months at 6 Month Assessment |
32; 28 | — |
| SECONDARY Percentage of Participants That Self-reported Use of Alcohol in Last 12 Months at Baseline |
31; 35 | — |
| SECONDARY Percentage of Participants That Self-reported Use of Alcohol in Last 12 Months at the 6-month Assessment |
29; 26 | — |
| SECONDARY Percentage of Participants With a Positive Urine Test for Any Drug at Baseline |
15; 24 | — |
| SECONDARY Percentage of Participants With a Positive Urine Test for Any Drug at the 6-month Assessment |
11; 15 | — |
| SECONDARY Percentage of Participants With a Positive Urine Test for Alcohol at the Baseline Assessment |
8; 20 | — |
| SECONDARY Percentage of Participants With a Positive Urine Test for Alcohol at the 6-month Assessment |
8; 12 | — |
Eligibility Criteria
Inclusion Criteria for AYLHIV:
- male or female AYLHIV aged 15-24 years;
- medically diagnosed with HIV and aware of their HIV status;
- enrolled in care at one of the selected HIV clinics.
- positive self-report or urine test for alcohol or drug use
Exclusion Criteria
- any AYLHIV with negative urine alcohol or drug use test and negative self-report for alcohol and drug use
- anyone with a significant cognitive impairment that interferes with their understanding of the informed consent process, or is unable/unwilling to consent.
Data sourced from ClinicalTrials.gov (NCT05597865). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.