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N/A Completed N=90 Randomized Single-blind Basic Science

The Effects of Mixed Working Memory Training on Subsequent Training Gains Among Older Adults

Cognitive Aging
Source: ClinicalTrials.gov NCT05672771 ↗
Enrolled (actual)
90
Serious AEs
0.0%
Results posted
Mar 2024
Primary outcomePrimary: Change in Overall Working Memory — 0.42; 0.26; -0.01; 0.04 Standard unit change — p=0.355

Summary

While an intellectually active and socially integrated lifestyle shows promise for promoting cognitive resilience, the mechanisms underlying any such effects are not well understood. The aim of the current project is test the implications of the "mutualism" hypothesis, which suggests that intellectual function emerges out of the reciprocal influence of growth in abilities as they are exercised in the ecology of everyday life. Such a view implies that improvement in one component will enhance the modifiability of a related component. An additional aim was to test the idea that mutualistic effects will be enhanced by more diverse training in related skills, such as interleaved training of multiple skills, relative to single-component training. A "successive-enrichment" paradigm was developed to test this with working memory (WM) as the target for training given its centrality in models of attention, intellectual function, and everyday capacities such as reasoning and language comprehension. All participants receive the same target training, but the nature of the training that precedes it is manipulated. Outcome measures include pre- to posttest gains in working memory and episodic memory, as well as the rate of gain in learning the target task. The principle of enhanced mutualism would predict that more diverse experiences related to the target skill will enhance efficiency in acquiring the target skill.

Outcome Measures

OutcomeResultp-value
PRIMARY
Change in Overall Working Memory
0.42; 0.26; -0.01; 0.04 0.355
PRIMARY
Change in Reading Span
0.70; 0.06; -0.03; 0.14 <.02 sig
SECONDARY
Training Gains on the Reading Span Task in Phase 2
.021; .034; .021; 0 <.05 sig

Eligibility Criteria

Inclusion Criteria

  • Native English speakers or acquisition of English before age 6 yrs old
  • Self-report of hearing ability sufficient to engage with lab personnel
  • No stroke in the last 3 years
  • No current cancer treatment involving radiation or chemotherapy - No self-reported learning disability
  • No self-reported psychiatric disorder
  • Willingness to be randomly assigned to training conditions
  • No plans that would limit participation during the activity period
  • No participation in a cognitive intervention program in the last year

No additional Exclusion Criteria.

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT05672771). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.

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