N/A
N=1,369
Impact of E-cigarette Device Warnings
Vaping Behaviors
Bottom Line
View on ClinicalTrials.gov: NCT05714982 ↗Enrolled (actual)
1,369
Serious AEs
0.0%
Results posted
Sep 2025
Primary outcome: Primary: Mean Vaping Quit Intentions Score — 2.5; 2.5; 2.2 score on a scale — p=<.001
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Label with text health warning (Other); Label with pictorial health warning (Other); Label with neutral statements about vaping (Other)
- Age
- Adult, Older Adult · 21+ yrs
- Sex
- All
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
- Primary completion
- Jul 2024
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Mean Vaping Quit Intentions Score |
2.5; 2.5; 2.2 | <.001 sig |
| SECONDARY Mean Knowledge Score |
0.6; 0.6; 0.4 | <.001 sig |
| SECONDARY Mean Cognitive Elaboration Score |
2.7; 2.9; 2.0 | <.001 sig |
| SECONDARY Mean Perceived Likelihood of Illness Score |
3.1; 3.1; 2.9 | .001 sig |
| SECONDARY Mean Negative Affect Score |
2.1; 2.3; 1.4 | <.001 sig |
| SECONDARY Mean Attention Score |
3.1; 3.3; 2.8 | <.0001 sig |
| SECONDARY Mean Information Seeking Score |
1.3; 1.4; 0.8 | <.001 sig |
| SECONDARY Mean Number of Conversations in Past Week |
1.5; 1.7; 1.2 | .03 sig |
| SECONDARY Mean Vaping Reinforcement Attitudes Score |
4.1; 4.1; 4.2 | .61 |
| SECONDARY Mean Uncontrolled Vaping Score |
2.4; 2.4; 2.3 | .4 |
| SECONDARY Mean Number of Times Forgoing a Vape in Past Week |
1.7; 1.7; 1.3 | .001 sig |
| SECONDARY Percent of Participants Who Made a Vaping Quit Attempt in Past 4 Weeks |
217; 204; 211 | — |
| SECONDARY Percent of Participants Who Successfully Quit Vaping |
7.2; 7.4; 3.7 | — |
| SECONDARY Mean Inaccurate Risk Perception Score |
0.42; 0.44; 0.48 | .02 sig |
| SECONDARY Mean Stigma Score |
1.9; 2.0; 1.6 | <.001 sig |
| SECONDARY Mean Smoking Quit Intentions Score |
2.4; 2.5; 2.3 | 0.3 |
| SECONDARY Percent of Participants Who Made a Smoking Quit Attempt in Past 4 Weeks |
54.3; 67.9; 63.1 | — |
Summary
The purpose of this randomized clinical trial is to determine whether e-cigarette warnings increase intentions to quit vaping without the unintended consequence of pushing users toward smoking. This trial addresses these issues by evaluating the impact of e-cigarette warnings by randomly assigning vapers to have their devices and refills labeled with control messages, text warnings, or pictorial warnings. Participants will be US adult (ages 21+) vapers. The trial expects ~1,200 participants to complete Visits 1, 3, and 5.
Eligibility Criteria
Inclusion Criteria
- Be 21 years or older
- Currently vape every day or some days
- Use an e-cigarette that contains nicotine
- Be able to attend 2 in-person appointments
- Be able to bring in e-cigarette device and 2 weeks' worth or refills to 2 in-person appointments
- Be willing to let us apply a sticker to the device and refill materials
- Be willing to use only the labeled e-cigarette during the study
- Be able to complete 3 surveys online at home
- Be able to read and speak English
- Be able to complete a survey on a computer without help
Exclusion Criteria
- Pregnant people
- If e-cigarette device cannot be labeled
- Vapers concurrently enrolled in any research studies about vaping or using other tobacco products
- Vapers who live in the same household as someone who has enrolled in the study
Data sourced from ClinicalTrials.gov (NCT05714982). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.