N/A Completed N=29 Randomized Triple-blind Other

Blueberries, Inflammation, Motivation, and Physical Activity

Depressive Symptoms

Source: ClinicalTrials.gov NCT05735587 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Jul 2025

Primary outcomePrimary: Change in Engagement in Physical Activity — 318; 346 steps per day

Summary

The purpose of this study is to determine the feasibility and preliminary efficacy of daily supplementation of freeze-dried blueberry to modulate inflammation-driven lack of motivation in 40 sedentary, older adults with depressive symptoms.

Outcome Measures

Outcome	Result	p-value
PRIMARY Change in Engagement in Physical Activity	318; 346	—
SECONDARY Study Recruitment Feasibility	12; 10	—
SECONDARY Change in Motivation	4; 0	—
SECONDARY Change in Inflammatory Marker - C-Reactive Protein	0.6; -1.6	—
SECONDARY Change in Inflammatory Marker - Interleukin-6	-0.5; -0.7	—
SECONDARY Change in Inflammatory Marker - Brain Derived Neurotrophic Factor	1.258; -1.226	—

Eligibility Criteria

Inclusion Criteria

Men and women aged ≥65 years
Self-reporting ≥ 8 hours of sitting per/day (e.g., sedentary behavior)
Depressive symptoms (defined as ≥4 and 7,500 steps per day (as measured by the ActiGraph), or per discretion of the PI
Cognitive impairment (defined as Montreal Cognitive Assessment, MoCA 2 points)
Current alcohol use disorder (Alcohol Use Disorders Identification Test - Consumption, AUDIT-C≥4 points)
Unstable anti-depressant use (e.g., change in medication within last 3-6 months), or per discretion of the PI
Current homicidal or suicidal ideation (assessed via the P4 Suicidality Screener)
Current psychosis (via the Psychosis and Hallucinations Questionnaire, PHQ>12 points)
Manic symptoms (assessed by the Mood Disorder Questionnaire, MDQ >5 points)

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT05735587). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.