Phase 2 N=97 Assessing Symptomatic Clinical Episodes in Depression
Major Depressive Disorder
Primary: MADRS Score - Overall Change From Baseline — 13.7; 8.8 score on a scale — p=<.001
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Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=1,089 Survey on PD Patients With Depressive Symptoms
Parkinson Disease
Primary: Percentage of Participants With Adverse Events, Adverse Drug Reactions, and Serious Adverse Events — 21.7; 19.2; 2.5 percentage of participants
N/A N=94 Stress and the Sympathetic Nervous System in Adults With Depression
Major Depressive Disorder
Primary: Percent of Days Participants Report Stressors — 36; 40 percent of days
Phase 4 N=22 Duloxetine for Menopausal Depression
Depression · Menopause · Vasomotor Symptoms
Primary: Change in Depression Scores as Measured by the Hamilton Rating Scale for Depression — -7.5 units on a scale
Phase 4 N=100 Antidepressant Response in the Treatment of Depressive Symptoms and Frailty Characteristics in Older Adults
Major Depressive Disorder · Dysthymic Disorder · Depressive Disorder, NOS
Primary: Hamilton Rating Scale for Depression (HRSD) — 13.3 score on a scale
N/A N=64 Virtual Reality Compared to Screen Based Engagement on Mood
Virtual Reality
Primary: Change in Positive Affect and Negative Affect From Baseline to After a 2 Minute Mood Induction — 3.7; 4.63; 1.97; 1.56 units on a scale
N/A N=41 Self-Management of Chronic Depressive Symptoms in Pregnancy
Depression
Primary: Recruitment Data — 41 Participants
N/A N=286 Non-motor Symptoms (Depressive Symptoms) of Parkinson's Disease and Their Course Under Pramipexole Treatment
Parkinson Disease
Primary: Change From Baseline in Unified Parkinson's Disease Rating Scale (UPDRS) Part I (Mentation, Behaviour and Mood) — 2; 2 Points on a scale
Phase 1 N=64 Lipopolysaccharide (LPS) Challenge in Depression
Major Depressive Disorder
Primary: Change in Snaith-Hamilton Pleasure Scale (SHAPS) — 38.4; 33.2; 27.2; 26.2 units on a scale
N/A N=205 Depression Attention for Women Now (The DAWN Study)
Depressive Disorder
Primary: Depression Treatment Outcome — 0.96; 1.33 units on a scale
N/A N=108 A Personalized Approach to Effects of Affective Bias Modification on Symptom Change and Rumination
Major Depressive Disorder
Primary: Self-reported Depressive Symptoms: Becks Depression Inventory-II — 19.1; 16.5; 5.3 score on a scale — p=.05
N/A N=655 Brief Video Interventions for Depression
Depressive Symptoms
Primary: Change in the Quick Inventory of Depressive Symptoms-Self Report (QIDS-SR) — 13.67; 14.09; 14.29; 13.79 units on a scale — p=.54
Phase 4 N=88 Evaluation of Depression Symptoms and Brain Activity Associated With Response to Treatment of Depression
Depression
Primary: Response as Assessed by Participants' Change in Depression Rating — 17; 11; 1; 9 Participants
Phase 4 N=16 Identifying and Treating Depression in Hemodialysis Patients
Depression · Hemodialysis-Induced Symptom
Primary: To Determine the Impact of Directly Observed Weekly Fluoxetine Treatment on Remission of Depression Among Hemodialysis Patients. — 6.6 units on a scale
N/A N=2,452 Testing Scalable, Single-Session Interventions for Adolescent Depression in the Context of COVID-19
Depression
Primary: Change in Adolescent Depressive Symptom Severity — 14.31; 14.15; 14.22; 12.57 Score on a scale
N/A N=9,110 Assessment of Somatic Symptom in Chinese Community-Dwelling People
Somatization Disorder
Primary: Number of Participants With Somatic Symptoms Disorder — 4307; 1000; 2507; 1206 Participants
Phase 4 N=27 The Effect on Depressive Symptoms in ECF Residents With COPD
Chronic Obstructive Pulmonary Disease · Depression
Primary: To Determine the Effect of Treating COPD Patients With Advair Diskus for 16 Weeks on the Cornell Depression Scale or Section D SUM of the Minimum Data Set 3.0 — 8.7…
N/A N=21 A Pilot Study of the Immediate Effects of DLPFC tDCS on Attention Bias in Depression
Depression
Primary: Beck Depression Inventory (BDI-II) Score — 21.29 score on a scale
N/A N=20 Cognitive Training Video Game to Target Subclinical Depressive Symptoms in Youth
Depression · Subclinical Depressive Symptoms
Primary: Change in Depressive Symptoms as Measured by Children's Depression Inventory (CDI) — 8.85; 5.84 score on a scale
N/A N=24 Omega-3 for Peri- and Postmenopausal Depression
Depression
Primary: Change in MADRS Score — 12.0 units on a scale
N/A N=48 Group Depression Treatment for Autistic Youth
Autism Spectrum Disorder · Depression · Suicidal Ideation
Primary: Change in Severity of Adolescent Depressive Symptoms, Self-report — 8.14 T-score
Phase 4 N=106 Aging Brain Changes, Executive Dysfunction and Depression
Depression
Primary: Hamilton Depression Rating Scale. — 8.09 units on a scale
Phase 4 N=95 Stress and Inflammation in Late-Life Depression
Depression · Inflammation
Primary: IL-6 Levels — 5.25; 18.24; 3.69; 6.84 pg/mL — p=.44
Phase 4 N=480 Study Comparing Discontinuation Symptoms Of DVS SR In Subjects With Major Depressive Disorder (MDD)
Major Depressive Disorder
Primary: Total Discontinuation - Emergent Signs and Symptoms (DESS) Score Over the First 2 Weeks of the Double-blind Phase — 4.1; 4.8; 5.3 scores on a scale
N/A N=1,001 The Effects of Videogames on Depression Symptoms and Brain Dynamics
Major Depressive Disorder
Primary: PHQ-9 Total Change From Baseline to Posttreatment: Experimental Group vs. Treatment as Usual Group — -1.941; -0.803 adjusted score change — p=0.0000022
N/A N=36 Effect of Amygdala Neurofeedback on Depressive Symptoms and Processing Biases
Major Depressive Disorder
Primary: Change From Baseline in Montgomery Asberg Depression Rating Scale at 2 Weeks — 23.5; 23.8; 11.9; 21.9 units on a scale — p=<0.001
N/A N=47 Online Peer Networked Collaborative Learning for Managing Depressive Symptoms
Depression
Primary: Patient Health Questionnaire - 9 (PHQ-9) - Depression Severity Module — -5.4; -4.8; -1.1 units on a scale — p=< .001
Phase 4 N=296 Pramipexole Versus Placebo in Parkinson's Disease (PD) Patients With Depressive Symptoms
Parkinson Disease · Depression
Primary: Change From Baseline in the Beck Depression Inventory-Version 1A (BDI-IA) Total Score at Week 12 — -4; -5.9 Score on scale — p=0.0103
N/A N=80 Coping With Depression in Parkinson's Disease
Parkinson's Disease · Depression
Primary: Hamilton Depression Rating Scale: Baseline — 20.93; 19.38 units on a scale
N/A N=77 Internet Based Cognitive Behavioral Therapy Effects on Depressive Cognitions and Brain Function
Major Depressive Disorder
Primary: Change From Pre-treatment to Post-treatment (10 Weeks), Measured by the Hamilton Rating Scale for Depression, 17 Item Version (HRSD-17). — 15.73; 15.70; 9.17; 14.05…