N/A
N=135
Investigation of Mohs Surgical Margins Using Two Photon Microscopy
Basal Cell Carcinoma
Bottom Line
View on ClinicalTrials.gov: NCT05814900 ↗Enrolled (actual)
135
Serious AEs
0.0%
Results posted
Mar 2026
Primary outcome: Primary: Agreement Between Frozen Sections and Two Photon Fluorescence Microscopy on Mohs Margins — 72.7; 96.8 Percentage
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Two photon microscopy imaging (Device)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- University of Rochester
- Primary completion
- Jun 2025
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Agreement Between Frozen Sections and Two Photon Fluorescence Microscopy on Mohs Margins |
72.7; 96.8 | — |
| SECONDARY Specificity of Frozen Sections and Two-photon Fluorescence Microscopy Accounting for Errors Caused Frozen Section Artifacts |
97.8; 91.1 | 0.017 sig |
| SECONDARY Sensitivity of Frozen Sections and Two-photon Fluorescence Microscopy on True Margin Diagnosis |
97.1; 94.1 | 0.0047 sig |
Summary
The goal of this clinical trial is to compare the use of two photon fluorescence microscopy for detecting residual basal cell carcinoma during Mohs surgery. The main question it aims to answer is:
• How similar are diagnosis of surgical margins to on two photon fluorescence microscopy compared to frozen section histology
Eligibility Criteria
Inclusion Criteria
- Undergoing treatment for BCC with Mohs surgery at the performance site
- Able to read and understand consent form
Exclusion Criteria
- None
Data sourced from ClinicalTrials.gov (NCT05814900). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.