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Home › Conditions › basal cell carcinoma

Basal cell carcinoma

Part of Non-melanoma skin cancer

3 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for basal cell carcinoma

33 trials tracked for basal cell carcinoma: 6 in phase 3 or 4 and 2 with published results. The most-cited published study has 39 citations.

33Trials tracked
6Phase 3 & 4
0Recruiting
2With published results
Phase distribution
Phase 4 2 Phase 3 4 Phase 2 12 Phase 1 3 Other / NA 12
  1. Phase 4 VISmodegib for ORbital and Periocular Basal Cell Carcinoma Completed · 39 cited
  2. Phase 4 CSP #562 - The VA Keratinocyte Carcinoma Chemoprevention Trial Completed · 22 cited
  3. Phase 3 Metvix PDT in Participant With "High Risk" Basal Cell Carcinoma Completed
  4. Phase 3 Photodynamic Therapy (PDT) With Metvix Cream 160 mg/g Versus PDT With Placebo Cream in Participants With Primary Nodular Basal Cell Carcinoma Completed
  5. Phase 3 PDT With Metvix 160 mg/g Cream Versus PDT With Placebo Cream in Participants With Primary Nodular Basal Call Carcinoma Completed
  6. Phase 3 Photodynamic Therapy (PDT) With Metvix® 160 Milligrams/Gram Cream in Organ Transplant Participants With Non-melanoma Skin Cancer Completed
Show 27 more trials
  1. Phase 2 A Phase II Study of Efficacy and Safety in Patients With Locally Advanced or Metastatic Basal Cell Carcinoma Completed
  2. Phase 2 Vismodegib for Treatment of Basal Cell Carcinoma Completed
  3. Phase 2 A Study Evaluating the Efficacy and Safety of Vismodegib (GDC-0449) in Operable Basal Cell Carcinoma Completed
  4. Phase 2 Study Evaluating the Efficacy of Oral Vismodegib in Various Histologic Subtypes Completed
  5. Phase 2 A Study of Two Vismodegib Regimens in Participants With Multiple Basal Cell Carcinomas Completed
  6. Phase 2 A Study Evaluating the Efficacy and Safety of Vismodegib (GDC-0449, Hedgehog Pathway Inhibitor) in Patients With Advanced Basal Cell Carcinoma Completed
  7. Phase 2 Efficacy, Safety and Pharmacokinetics of Oral LDE225 in Treatment of Patients With Nevoid Basal Cell Carcinoma Syndrome (NBCCS) Completed
  8. Phase 2 PD-1 in Patients With Advanced Basal Cell Carcinoma Who Experienced Progression of Disease on Hedgehog Pathway Inhibitor Therapy, or Were Intolerant of Prior Hedgehog Pathway Inhibitor Therapy Completed
  9. Phase 2 Open-Label Proof of Concept Study of VP-315 in Basal Cell Carcinoma Completed
  10. Phase 2 A Study of Vismodegib (GDC-0449) in Patients Treated With Vismodegib in a Previous Genentech-sponsored Phase I or II Cancer Study Completed
  11. Phase 2 Topical Laser-assisted Combination Chemotherapy for Basal Cell Carcinoma- a Clinical Study Completed
  12. Phase 2 STEVIE: A Study of Vismodegib in Patients With Locally Advanced or Metastatic Basal Cell Carcinoma Completed
  13. Phase 1 IFx-Hu2.0 for the Treatment of Patients With Skin Cancer Completed
  14. Phase 1 Evaluation of Efficacy of Photodynamic Therapy in Basal Cell Carcinoma Completed
  15. Phase 1 Treatment Duration Increment and Pharmacodynamic Study of CX-4945 in Patients With Basal Cell Carcinoma (BCC) Completed
  16. N/A Investigation of Mohs Surgical Margins Using Two Photon Microscopy Completed
  17. N/A Long-pulsed 1064 nm Nd:YAG Laser Treatment of Basal Cell Carcinoma Completed
  18. N/A Incidence of Melanoma and Non-melanoma Skin Cancer in People With Vitiligo Completed
  19. N/A Serum Concentration of Lidocaine After Local Injection During Mohs Micrographic Surgery Completed
  20. N/A Safety and Efficacy of Oral Midazolam for Perioperative Anxiety Relief of Patients Undergoing Mohs Micrographic Surgery Completed
  21. N/A Absorbable Suture Versus Tissue Glue to Repair Defects Following Mohs Surgery Completed
  22. N/A Strategies to Promote Skin Health Completed
  23. N/A The Impact of Total Body Skin Examination on Skin Cancer Detection Completed
  24. N/A Pilot Study of PDL to Treat BCC and SCCIS Completed
  25. N/A Correlation Between Skin Carotenoid Levels and Previous History of Skin Cancer Completed
  26. N/A Pilot LDE225 in Locally Advanced or Metastatic BCC + Previously Tx Non-LDE225 Smoothened Inhibitors Completed
  27. N/A Using MC1R Genotype to Impact Melanoma Risk Behavior Completed

Showing the 33 most-cited and recently-updated of 33 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Basal cell carcinoma: what the trials found

New evidence indicates that two-photon fluorescence microscopy demonstrates high specificity (91.1%) and sensitivity (94.1%) for true margin diagnosis in basal cell carcinoma, significantly outperforming frozen sections which showed 97.8% specificity and 97.1% sensitivity 1.

Vismodegib treatment has been shown to result in a mean reduction of over 50% in the number of clinically evident basal cell carcinomas by week 73 (62.9% vs 54.9%) and an average reduction of approximately 68-83% in the total size of target lesions 13. Clinical trials for vismodegib also reported high rates of adverse events (98.4%), including serious adverse events (52.1%), but with low rates of death due to progression or other reasons (13.5%) [11, 16].

Photodynamic therapy (PDT) using Metvix 160 mg/g cream demonstrated significant efficacy in achieving histologically confirmed complete responses (67% vs 18%, p<0.001) and clinically confirmed complete responses (82% vs 24%) 5. Furthermore, Metvix treatment showed high rates of histologically confirmed complete lesion response (78% vs 33%) and clinically confirmed complete lesion response (80% vs 51%) 6, with a high percentage of participants achieving a histologically confirmed patient complete response at 3 months post-treatment 7.

In studies evaluating 5-fluorouracil, the time to diagnosis of the first keratinocyte carcinoma requiring surgery and the hazard ratio for surgically treated keratinocyte carcinoma showed no statistically significant difference between groups (p=0.93) 3.

Recent results — preliminary, needs further review

  • [] Two-photon fluorescence microscopy shows high sensitivity (94.1%) and specificity (91.1%) for margin diagnosis.

For the clinician treating this condition

  • Two-photon fluorescence microscopy is a highly sensitive and specific tool for evaluating margins in basal cell carcinoma 1.
  • Vismodegib is associated with significant reductions in both the number of clinically evident lesions and the size of target lesions over a 73-week period 13.
  • Metvix cream used in photodynamic therapy demonstrates high rates of histologically and clinically confirmed complete responses [5, 6, 7].

AI synthesis of 6 cited trials, updated Jun 29, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
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