N/A Completed N=20 Randomized Triple-blind Other

Berries, Bugs, and the Blues

Depressive Symptoms

Source: ClinicalTrials.gov NCT05817383 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Aug 2025

Primary outcomePrimary: Depressive Symptom Severity — -5; -4 scores on a scale

Summary

This study aims to investigate the impact of daily freeze-dried blueberry powder consumption on the gut microbiota, fecal short chain fatty acids, and depressive symptom severity in 40older, sedentary adults with depressive symptoms.

Outcome Measures

Outcome	Result	p-value
PRIMARY Depressive Symptom Severity	-5; -4	—
SECONDARY Abundance Microbes	1.28; 1.63	—
SECONDARY Fecal Short Chain Fatty Acids (i.e., Butyrate)	-2; 27	—

Eligibility Criteria

Inclusion Criteria

Men and women aged ≥65 years
Self-reporting ≥ 8 hours of sitting per/day (e.g., sedentary behavior)
Depressive symptoms (defined as ≥4 and 7,500 steps per day (as measured by the ActiGraph), or per discretion of the PI
Cognitive impairment (defined as Montreal Cognitive Assessment, MoCA 2 points)
Current alcohol use disorder (Alcohol Use Disorders Identification Test - Consumption, AUDIT-C≥4 points)
Unstable anti-depressant use (e.g., change in medication within last 3-6 months), or per discretion of the PI
Current homicidal or suicidal ideation (assessed via the P4 Suicidality Screener)
Current psychosis (via the Psychosis and Hallucinations Questionnaire, PHQ>12 points)
Manic symptoms (assessed by the Mood Disorder Questionnaire, MDQ >5 points)

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT05817383). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.