N/A N=52 Randomized Triple-blind Treatment

Impact of E-cigarette Nicotine Concentration on Compensation

Smoking Cessation

Bottom Line

View on ClinicalTrials.gov: NCT05887947 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Sep 2025

Primary outcome: Primary: Total Inhaled Volume — 416.5; 490.3 mL

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: Electronic Cigarette with 5% Nicotine Concentration (Device); Electronic Cigarette with 1.8% Nicotine Concentration (Device)
Age: Adult, Older Adult · 21+ yrs
Sex: All
Sponsor: University of Kansas Medical Center
Primary completion: May 2024

Outcome Measures

Outcome	Result	p-value
PRIMARY Total Inhaled Volume	416.5; 490.3	—
SECONDARY Participant Switch Trajectory	10; 6; 10; 13; 3; 0	—

Summary

The study will be the first to assess the impact of nicotine concentration on compensatory puffing (total inhaled volume), nicotine delivery, and switch patterns (percent exclusive EC, dual cig-EC, and cig only users) with an explicit focus on AA and White smokers.

Eligibility Criteria

Inclusion Criteria

identify as non-Hispanic white or non-Hispanic African American/Black
willing to switch from smoking to e-cigarettes for 6 weeks
speak and understand English
smoke greater than or equal to 25 of the last 30 days for the past 3 months
not previously used an e-cigarette for longer than 30 days
exhaled carbon monoxide of greater than or equal to 6ppm at screener visit
willing to abstain from marijuana for 12 hours prior to in-person lab visits
willing to abstain from smoking and vaping for 12 hours prior to 3 in-person lab visits

Exclusion Criteria

weekly use of an EC over the last six months
use of tobacco products other than cigarettes on greater than or equal to 10 days in the past 30 days
use of EC on more than 5 of the past 30 days
current use of cessation medications
pregnant, planning to become pregnant, or breastfeeding
past 30 day hospitalization/ER visit for psychiatric issue, seizure, stroke, or new heart problem
recent history of cardiovascular or pulmonary events in the past three months
treatment for alcohol or drug dependence in the past year
household member currently or previously enrolled in the study
current enrollment in a program aimed at changing smoking patterns

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT05887947). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.